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首页> 外文期刊>Chemistry: A European journal >Extraordinary Modulation of Disulfide Redox-Responsiveness by Cooperativity of Twin-Disulfide Bonds
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Extraordinary Modulation of Disulfide Redox-Responsiveness by Cooperativity of Twin-Disulfide Bonds

机译：双二硫键的协同作用对二硫键氧化还原反应的非凡调节

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Disulfide bonds have frequently been incorporated into synthetic materials to promote sensitivity of the systems towards different redox environments. Although many strategies have been developed to rationally tune the stability of disulfide linkers, methods to tune their responsiveness towards different redox environments remain elusive. In this work we have developed and explored a disulfide linker bearing two independent disulfide bonds, referred to as a twin-disulfide linker. We have demonstrated that the twin-disulfide linker displays an ultrahigh stability at lower concentrations of reducing agent or in weakly reducing environments without a significant compromise in the sensitivity of its response to highly reducing environments such as cytoplasm, a feature that is in remarkable contrast to the traditional single disulfide bonds. Such an extraordinary responsiveness arises from the cooperativity of the twin-disulfide bonds, which should be of particular interest for applications such as controlled drug delivery and sensing, because relatively large differences in disulfide stability in different redox environments is desired in these applications.
机译：通常将二硫键结合到合成材料中，以提高系统对不同氧化还原环境的敏感性。尽管已经开发了许多策略来合理地调节二硫键的稳定性，但是调节其对不同氧化还原环境的响应性的方法仍然难以实现。在这项工作中，我们开发并探索了带有两个独立的二硫键的二硫键，称为双二硫键。我们已经证明，双-二硫键在较低浓度的还原剂或弱还原环境下显示出超高的稳定性，而对高还原环境（如细胞质）的反应敏感性没有显着降低，这一特点与传统的单二硫键。这种非凡的响应性是由双二硫键的协同作用引起的，这对于诸如受控药物递送和传感的应用应该是特别有意义的，因为在这些应用中需要不同氧化还原环境中二硫稳定性的相对较大的差异。

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