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首页> 外文期刊>Chemistry: A European journal >Multivalency in the Gas Phase: H/D Exchange Reactions Unravel the Dynamic 'Rock 'n' Roll' Motion in Dendrimer-Dendrimer Complexes
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Multivalency in the Gas Phase: H/D Exchange Reactions Unravel the Dynamic 'Rock 'n' Roll' Motion in Dendrimer-Dendrimer Complexes

机译：气相中的多价：H / D交换反应揭示了树枝状聚合物-树枝状聚合物络合物中的动态“摇滚”运动

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Noncovalent dendrimer-dendrimer complexes were successfully ionized by electrospray ionization of partly protonated amino-terminated polypropylene amine (POPAM) and POPAM dendrimers fully functionalized with benzo[21]crown-7 on all branches. Hydrogen/deuterium exchange (HDX) experiments conducted on dendrimer-dendrimer complexes in the high vacuum of a mass spectrometer give rise to a complete exchange of all labile NH hydrogen atoms. As crown ethers represent noncovalent protective groups against HDX reactions on the ammonium group to which they are coordinated, this result provides evidence for a very dynamic binding situation: each crown is mobile enough to move from one ammonium binding site to another. Schematically, one might compare this motion with two rock 'n' roll dancers that swirl around each other without completely losing all contact at any time. Although the multivalent attachment certainly increases the overall affinity, the "micro-dynamics" of individual site binding and dissociation remains fast.
机译：非共价树状聚合物-树状聚合物复合物已通过电喷雾电离部分质子化的氨基封端的聚丙烯胺（POPAM）和在所有分支上均被苯并[21] crown-7完全官能化的POPAM树状聚合物成功地电离。在质谱仪的高真空下对树枝状聚合物-树枝状聚合物络合物进行的氢/氘交换（HDX）实验可以完全交换所有不稳定的NH氢原子。由于冠醚代表针对它们所协调的铵基上的HDX反应的非共价保护基团，因此该结果为非常动态的结合情况提供了证据：每个冠具有足够的移动性，可从一个铵结合位点移动至另一个铵结合位点。从原理上讲，可以将此动作与两个旋转的摇滚舞者进行比较，而舞者在任何时候都不会完全失去接触。尽管多价连接确实增加了整体亲和力，但单个位点结合和解离的“微观动力学”仍然保持快速。

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