Structure and Biosynthetic Assembly of Gulmirecins, Macrolide Antibiotics from the Predatory Bacterium Pyxidicoccus fallax

Schieferdecker Sebastian; Koenig Stefanie; Weigel Christiane; Dahse Hans-Martin; Werz Oliver; Nett Markus

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Structure and Biosynthetic Assembly of Gulmirecins, Macrolide Antibiotics from the Predatory Bacterium Pyxidicoccus fallax

机译：掠食性细菌Pyxidicoccus fallax的大环内酯类抗生素Gulmirecins的结构和生物合成

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The gulmirecins constitute a new class of glycosylated macrolides that were isolated from the predatory bacterium Pyxidicoccus fallax HKI 727. Their structures were solved by a combination of NMR spectroscopic experiments and chemical derivatization. Analysis of the annotated gulmirecin gene cluster complemented the configurational as-signment and provided insights into the stereochemical course of the biosynthetic assembly. The gulmirecins exhibit strong activity against staphylococci, including methicillin-resistant Staphylococcus aureus, but no cytotoxic effects on human cells.

机译：甘菊酯类化合物是一类新的糖基化大环内酯类化合物，它们是从掠食性细菌毕赤酵母（Pyxidicoccus fallax HKI 727）中分离出来的。它们的结构通过NMR光谱实验和化学衍生化的结合而得到解决。对带注释的古尔霉素基因簇的分析补充了构型分配，并提供了对生物合成组装体立体化学过程的见解。甲氨蝶呤对葡萄球菌（包括耐甲氧西林的金黄色葡萄球菌）表现出强大的活性，但对人体细胞无细胞毒性作用。

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《Chemistry: A European journal》 |2014年第48期|共8页
作者
Schieferdecker Sebastian; Koenig Stefanie; Weigel Christiane; Dahse Hans-Martin; Werz Oliver; Nett Markus;
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正文语种 eng
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antibiotics; natural products; NMR spectroscopy; polyketides; structure elucidation;

机译：抗生素;天然产物;核磁共振谱;聚酮;结构阐明;

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1. Structure and Biosynthetic Assembly of Gulmirecins, Macrolide Antibiotics from the Predatory Bacterium Pyxidicoccus fallax [J] . Schieferdecker Sebastian, Koenig Stefanie, Weigel Christiane, Chemistry: A European journal . 2014,第48期

机译：掠食性细菌Pyxidicoccus fallax的大环内酯类抗生素Gulmirecins的结构和生物合成
2. Disciformycins A and B: 12-Membered Macrolide Glycoside Antibiotics from the Myxobacterium Pyxidicoccus fallax Active against Multiresistant Staphylococci [J] . Surup Frank, Viehrig Konrad, Mohr Kathrin I., Angewandte Chemie . 2014,第49期

机译：Disciformycins A和B：来自黏液杆菌Pyxidicoccus fallax的12元大环内酯糖苷类抗生素具有抗多重耐药葡萄球菌的活性
3. Disciformycins A and B: 12-Membered Macrolide Glycoside Antibiotics from the Myxobacterium Pyxidicoccus fallax Active against Multiresistant Staphylococci [J] . Surup Frank, Viehrig Konrad, Mohr Kathrin I., Angewandte Chemie . 2014,第49期

机译：Disciformycins A和B：来自黏液杆菌Pyxidicoccus fallax的12元大环内酯糖苷类抗生素具有抗多重耐药葡萄球菌的活性
4. Characterization of the biosynthetic gene cluster of the polyene macrolide antibiotic reedsmycins from a marine-derived Streptomyces strain [O] . Tingting Yao, Zengzhi Liu, Tong Li, 2018

机译：海洋衍生链霉菌菌株多烯大环内酯类抗生素芦苇霉素的生物合成基因簇的表征
5. Inducible Resistance to Macrolide-Lincosamide-Streptogramin Type B Antibiotics In Bacillus licheniformis : Common Structures of Macrolide Antibiotics Capable of Inducing the Resistance [O] . Hiroyuki KOBAYASHI, Kikutarou ENDOU, Yoshinori NAKAJIMA 1993

机译：令人触手抗性抗植物 - 林磷脂 - 链条型Bacillus LiCheniformis的B型抗生素：能够诱导抗性的大环内酯抗生素的常见结构

Structure and Biosynthetic Assembly of Gulmirecins, Macrolide Antibiotics from the Predatory Bacterium Pyxidicoccus fallax

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