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首页> 外文期刊>Chemistry: A European journal >General Protocol for the Synthesis of Functionalized Magnetic Nanoparticles for Magnetic Resonance Imaging from Protected Metal–Organic Precursors
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General Protocol for the Synthesis of Functionalized Magnetic Nanoparticles for Magnetic Resonance Imaging from Protected Metal–Organic Precursors

机译：从受保护的金属有机前驱体合成用于磁共振成像的功能化磁性纳米粒子的通用协议

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摘要

The development of magnetic nanoparticles (MNPs) with functional groups has been intensively pursued in recent years. Herein, a simple, versatile, and cost-effective strategy to synthesize water-soluble and amino-functionalized MNPs, based on the thermal decomposition of phthalimide- protected metal–organic precursors followed by deprotection, was developed. The resulting amino-functionalized Fe_3O_4, MnFe_2O_4, and Mn_3O_4 MNPs with particle sizes of about 14.3, 7.5, and 6.6 nm, respectively, had narrow size distributions and good dispersibility in water. These MNPs also exhibited high magnetism and relaxivities of r_2= 107.25 mM~(-1) s~(-1) for Fe_3O_4, r_2=245.75 mM~(-1) s~(-1) for MnFe_2O_4, and r_1=2.74 mM~(-1) s~(-1) for Mn_3O_4. The amino-functionalized MNPs were further conjugated with a fluorescent dye (rhodamine B) and a targeting ligand (folic acid: FA) and used as multifunctional probes. Magnetic resonance imaging and flow-cytometric studies showed that these probes could specifically target cancer cells overexpressing FA receptors. This new protocol opens a new way for the synthesis and design of water-soluble and amino-functionalized MNPs by an easy and versatile route.
机译：近年来，已经强烈地追求具有官能团的磁性纳米颗粒（MNP）的开发。在此，基于邻苯二甲酰亚胺保护的金属有机前体的热分解，然后进行脱保护，开发了一种简单，通用且具有成本效益的策略来合成水溶性和氨基官能化的MNP。所得的氨基官能化的Fe_3O_4，MnFe_2O_4和Mn_3O_4 MNP的粒径分别约为14.3、7.5和6.6 nm，具有窄的粒径分布和在水中的良好分散性。这些MNPs还表现出高磁性和弛豫性，Fe_3O_4的r_2 = 107.25 mM〜（-1）s〜（-1），MnFe_2O_4的r_2 = 245.75 mM〜（-1）s〜（-1），r_1 = 2.74 mM Mn_3O_4为〜（-1）s〜（-1）。氨基官能化的MNP进一步与荧光染料（若丹明B）和靶向配体（叶酸：FA）缀合，并用作多功能探针。磁共振成像和流式细胞术研究表明，这些探针可以特异性地靶向过度表达FA受体的癌细胞。该新方案为通过简单通用的途径合成和设计水溶性和氨基官能化MNP开辟了一条新途径。

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