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首页> 外文期刊>Chemistry: A European journal >Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools
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Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools

机译：基于刺激反应蛋白的仿生原细胞的纳米工程作为多功能药物递送工具。

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摘要

We present a general strategy to nanoengineer protein-based colloidal spheres (biomimetic protocells) as versatile delivery carriers with stimuli responsiveness by the electrostatic assembly of binary components (proteins and polypeptides) in association with intermolecular disulfide cross-linking. The size of the colloidal spheres, ranging from nanoscale to microscale, is readily tuned through parameters like protein and polypeptide concentration, the ratio between both, pH, and so on. Moreover, such colloidal spheres show versatile encapsulation of various guest molecules including small organic molecules and biomacromolecules. The pH and redox dual-responsiveness facilitates the rapid release of the payload in an acidic and reductant-enriched ambient such as in lysosomes. Thus, nanoengineering of protein-based biomimetic protocells opens a new alternative avenue for developing delivery vehicles with multifunctional properties towards a range of therapeutic and diagnostic applications.
机译：我们提出了一种基于纳米工程蛋白的胶体球（仿生原生细胞）作为通用递送载体的通用策略，该载体具有通过分子组件二硫键交联的二元组分（蛋白质和多肽）的静电组装而具有刺激响应性。胶体球的大小从纳米级到微米级不等，可以通过蛋白质和多肽浓度，两者之间的比率，pH值等参数轻松调整。而且，这种胶体球显示出各种客体分子的通用封装，包括小有机分子和生物大分子。 pH和氧化还原双重反应性有助于在酸性和富含还原剂的环境（如溶酶体）中快速释放有效负载。因此，基于蛋白质的仿生原始细胞的纳米工程为开发具有多功能特性的运载工具向一系列治疗和诊断应用开辟了一条新的替代途径。

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