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首页> 外文期刊>Chemistry: A European journal >Water-Soluble Molecularly Imprinted Nanoparticles (MINPs) with Tailored, Functionalized, Modifiable Binding Pockets
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Water-Soluble Molecularly Imprinted Nanoparticles (MINPs) with Tailored, Functionalized, Modifiable Binding Pockets

机译：具有量身定制的，功能化的，可修饰的结合口袋的水溶性分子印迹纳米颗粒（MINP）

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摘要

Construction of receptors with binding sites of specific size, shape, and functional groups is important to both chemistry and biology. Covalent imprinting of a photo-cleavable template within surface-core doubly cross-linked micelles yielded carboxylic acid-containing hydrophobic pockets within the water-soluble molecularly imprinted nanoparticles. The functionalized binding pockets were characterized by their binding of amine-and acid-functionalized guests under different pH values. The nanoparticles, on average, contained one binding site per particle and displayed highly selective binding among structural analogues. The binding sites could be modified further by covalent chemistry to modulate their binding properties.
机译：具有特定大小，形状和官能团的结合位点的受体的构建对于化学和生物学都至关重要。在表面核心双交联的胶束中共价刻印可光裂解模板，在水溶性分子印迹纳米粒子中产生了含羧酸的疏水性口袋。功能化的结合袋的特征在于它们在不同的pH值下结合胺和酸官能化的客体。平均而言，纳米粒子每个粒子包含一个结合位点，并且在结构类似物中表现出高度选择性的结合。结合位点可通过共价化学进一步修饰以调节其结合特性。

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