...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Behavioral neuroscience >BEHAVIORAL NEUROSCIENCE AT 30: REPRINTED ARTICLE Early Postnatal Handling Alters Glucocorticoid Receptor Concentrations in Selected Brain Regions
【24h】

BEHAVIORAL NEUROSCIENCE AT 30: REPRINTED ARTICLE Early Postnatal Handling Alters Glucocorticoid Receptor Concentrations in Selected Brain Regions

机译：30岁时的行为神经科学：弃用的文章产后早期处理改变了所选大脑区域的糖皮质激素受体浓度

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Norway rat pups were either handled (H) or undisturbed (nonhandled, NH) in the period between birth and weaning on Day 21. Following weaning, half of the animals in each group were housed socially(Soc), and half were housed in isolation (Isol). At 120 - 150 days of age, all animals were sacrificed, and the following regions were dissected and frozen at -70 °C until the time of assay: frontal cortex, hippocampus, hypothalamus, amygdala, septum, and pituitary. [3H]Dexamethasòne (3H Dex) binding in each region was examined by an in vitro, cytosol, receptor assay. 3H Dex binding was significantly higher in the hippocampus of both H-Soc and H-Isol than in NH groups. In the frontal cortex, 3H Dex binding was higher in the H-Soc animals than in the H-Isol and NH-Isol animals. There were no significant handling or housing effects found in the amygdala, hypothalamus, septum, or pituitary. Thus, early postnatal handling appears to influence the development of the glucocorticoid receptor system in the hippocampus and frontal cortex. These results are discussed as providing a possible mechanism for some of the previously reported effects of early handling on the development of the pituitary-adrenal response to stress.
机译：在出生至第21天断奶期间，对挪威幼崽进行处理（H）或不打扰（NH，不处理）。断奶后，每组一半的动物在社会上被圈养（Soc），一半的动物被单独圈养（Isol）。在120-150日龄时，处死所有动物，解剖以下区域并于-70°C冷冻直至测定时间：额叶皮层，海马，下丘脑，杏仁核，隔膜和垂体。通过体外细胞溶胶受体测定法检查每个区域中的[3H]地塞米松（3H Dex）结合。 H-Soc和H-Isol在海马中的3H Dex结合显着高于NH组。在额叶皮层中，H-Soc动物中的3H Dex结合高于H-Isol和NH-Isol动物。在杏仁核，下丘脑，隔膜或垂体中均未发现明显的处理或收容作用。因此，产后早期处理似乎会影响海马和额叶皮质糖皮质激素受体系统的发育。这些结果被讨论为早期报道的某些早期报道的作用对垂体-肾上腺对压力的反应的发展提供了可能的机制。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号