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首页> 外文期刊>Chemistry: A European journal >Mechanistic Insights into the Luminescent Sensing of Organophosphorus Chemical Warfare Agents and Simulants Using Trivalent Lanthanide Complexes
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Mechanistic Insights into the Luminescent Sensing of Organophosphorus Chemical Warfare Agents and Simulants Using Trivalent Lanthanide Complexes

机译：使用三价镧系元素配合物对有机磷化学战剂和模拟物进行发光传感的机理研究。

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摘要

Organophosphorus chemical warfare agents (OP CWAs) are potent acetylcholinesterase inhibitors that can cause incapacitation and death within minutes of exposure, and furthermore are largely undetectable by the human senses. Fast, efficient, sensitive and selective detection of these compounds is therefore critical to minimise exposure. Traditional molecular-based sensing approaches have exploited the chemical reactivity of the OP CWAs, whereas more recently supramolecular-based approaches using non-covalent interactions have gained momentum. This is due, in part, to the potential development of sensors with second-generation properties, such as reversibility and multifunction capabilities. Supramolecular sensors also offer opportunities for incorporation of metal ions allowing for the exploitation of their unique properties. In particular, trivalent lanthanide ions are being increasingly used in the OP CWA sensing event and their use in supramolecular sensors is discussed in this Minireview. We focus on the fundamental interactions of simple lanthanide systems with OP CWAs and simulants, along with the development of more elaborate and complex systems including those containing nanotubes, polymers and gold nanoparticles. Whilst literature investigations into lanthanide-based OP CWA detection systems are relatively scarce, their unique and versatile properties provide a promising platform for the development of more efficient and complex sensing systems into the future.
机译：有机磷化学战剂（OP CWA）是有效的乙酰胆碱酯酶抑制剂，可在暴露后数分钟内导致功能丧失和死亡，此外，人类的感觉大多无法检测到。因此，对这些化合物进行快速，有效，灵敏和选择性的检测对于最大限度地减少暴露至关重要。传统的基于分子的传感方法已经利用了OP CWA的化学反应性，而最近使用非共价相互作用的基于超分子的方法获得了发展势头。这部分归因于具有第二代特性（例如可逆性和多功能功能）的传感器的潜在发展。超分子传感器还提供了掺入金属离子的机会，从而可以利用其独特的性能。特别是，三价镧系离子正越来越多地用于OP CWA传感事件中，并且在本Minireview中讨论了它们在超分子传感器中的使用。我们将重点放在简单的镧系元素与OP CWA和模拟物之间的基本相互作用，以及更复杂，更复杂的系统（包括包含纳米管，聚合物和金纳米粒子的系统）的开发上。虽然对基于镧系元素的OP CWA检测系统的文献研究相对较少，但它们独特而通用的特性为将来开发更高效，更复杂的传感系统提供了一个有希望的平台。

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