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首页> 外文期刊>Chemistry: A European journal >New Found Hope for Antibiotic Discovery: Lipid II Inhibitors
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New Found Hope for Antibiotic Discovery: Lipid II Inhibitors

机译：抗生素发现的新发现希望：脂质II抑制剂

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摘要

Research into antibacterial agents has recently gathered pace in light of the disturbing crisis of antimicrobial resistance. The development of modern tools offers the opportunity of reviving the fallen era of antibacterial discovery through uncovering novel lead compounds that target vital bacterial cell components, such as lipid II. This paper provides a summary of the role of lipid II as well as an overview and insight into the structural features of macrocyclic peptides that inhibit this bacterial cell wall component. The recent discovery of teixobactin, a new class of lipid II inhibitor has generated substantial research interests. As such, the significant progress that has been achieved towards its development as a promising antibacterial agent is discussed.
机译：鉴于令人不安的抗微生物剂耐药性危机，最近对抗菌剂的研究加快了步伐。现代工具的开发提供了机会，通过发现针对重要细菌细胞成分（例如脂质II）的新型先导化合物，来复兴抗菌药物发现的衰落时代。本文概述了脂质II的作用，并对抑制这种细菌细胞壁成分的大环肽的结构特征进行了概述和见解。新型脂质II抑制剂teixobactin的最新发现引起了广泛的研究兴趣。因此，讨论了其作为有前途的抗菌剂的发展已取得的重大进展。

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