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首页> 外文期刊>Chemistry: A European journal >Thiomaltol-Based Organometallic Complexes with 1-Methylimidazole as Leaving Group: Synthesis, Stability, and Biological Behavior
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Thiomaltol-Based Organometallic Complexes with 1-Methylimidazole as Leaving Group: Synthesis, Stability, and Biological Behavior

机译：以1-甲基咪唑为离去基的基于硫代麦芽酚的有机金属配合物：合成，稳定性和生物学行为。

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摘要

Thiomaltol, a potential S,O-coordinating molecule, has been utilized for the complexation of four different organometallic fragments, yielding the desired Ru-II, Os-II, Rh-III, and Ir-III complexes having a piano-stool configuration. In addition to the synthesis of these compounds with a chlorido leaving group, the analogous 1-methylimidazole derivatives have been prepared, giving rise to thiomaltol-based organometallics with enhanced stability under physiological conditions. The organometallic compounds have been characterized by NMR spectroscopy, elemental analysis, and X-ray diffraction analysis. Their behavior in aqueous solution and their interactions with certain amino acids have been studied by ESI mass spectrometry. Their pH-dependent stability has been investigated by (HNMR)-H-1 in aqueous solution, and their cytotoxicity against three different cancer cell lines has been investigated. Furthermore, their capacity as topoisomerase II inhibitors as well as their effect on the cell cycle distribution and reactive oxygen species (ROS) generation have been elucidated.
机译：硫代麦芽酚，一种潜在的S，O配位分子，已被用于络合四种不同的有机金属片段，产生了具有钢琴凳构型的所需Ru-II，Os-II，Rh-III和Ir-III配合物。除了合成具有氯代离去基团的这些化合物外，还制备了类似的1-甲基咪唑衍生物，产生了在生理条件下具有增强的稳定性的基于硫代麦芽酚的有机金属化合物。有机金属化合物已通过NMR光谱，元素分析和X射线衍射分析进行了表征。通过ESI质谱研究了它们在水溶液中的行为以及它们与某些氨基酸的相互作用。通过（HNMR）-H-1在水溶液中研究了它们的pH依赖性稳定性，并研究了它们对三种不同癌细胞系的细胞毒性。此外，已经阐明了它们作为拓扑异构酶II抑制剂的能力以及它们对细胞周期分布和活性氧（ROS）生成的影响。

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