Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible-Light-Triggered Platform for Facile siRNA Delivery

Patil Sachin P.; Moosa Basem A.; Alsaiari Shahad; Alamoudi Kholod; Alshamsan Aws; AlMalik Abdulaziz; Adil Karim; Eddaoudi Mohamed; Khashab Niveen M.

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Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible-Light-Triggered Platform for Facile siRNA Delivery

机译：组氨酸封端的二烷氧基蒽的超分子自组装：可见光触发平台，方便的siRNA交付。

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Supramolecular self-assembly of histidine-capped-dialkoxy-anthracene (HDA) results in the formation of light-responsive nanostructures. Single-crystal Xray diffraction analysis of HDA shows two types of hydrogen bonding. The first hydrogen bond is established between the imidazole moieties while the second involves the oxygen atom of one amide group and the hydrogen atom of a second amide group. When protonated in acidic aqueous media, HDA successfully complexes siRNA yielding spherical nanostructures. This biocompatible platform controllably delivers siRNA with high efficacy upon visible-light irradiation leading up to 90% of gene silencing in live cells.

机译：组氨酸封端的二烷氧基蒽（HDA）的超分子自组装导致形成光响应纳米结构。 HDA的单晶X射线衍射分析显示出两种类型的氢键。第一个氢键在咪唑部分之间建立，而第二个涉及一个酰胺基的氧原子和第二个酰胺基的氢原子。当在酸性水性介质中质子化时，HDA成功地复合了siRNA，产生了球形纳米结构。这种生物相容性平台可控地在可见光照射下高效递送siRNA，导致活细胞中90％的基因沉默。

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《Chemistry: A European journal》 |2016年第39期|共5页
作者
Patil Sachin P.; Moosa Basem A.; Alsaiari Shahad; Alamoudi Kholod; Alshamsan Aws; AlMalik Abdulaziz; Adil Karim; Eddaoudi Mohamed; Khashab Niveen M.;
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正文语种 eng
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hydrogen bonding; photoresponsive; self-assembly; siRNA delivery; supramolecular chemistry;

机译：氢键;光响应;自组装;siRNA传递;超分子化学;

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1. Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible-Light-Triggered Platform for Facile siRNA Delivery [J] . Patil Sachin P., Moosa Basem A., Alsaiari Shahad, Chemistry: A European journal . 2016,第39期

机译：组氨酸封端的二烷氧基蒽的超分子自组装：可见光触发平台，方便的siRNA交付。
2. A supramolecular platform for controlling and optimizing molecular architectures of siRNA targeted delivery vehicles [J] . Yuting Wen, Hongzhen Bai, Jingling Zhu, Science Advances . 2020,第31期

机译：一种用于控制和优化siRNA靶向送货车的分子架构的超分子平台
3. Facile construction of shape-regulated beta-cyclodextrin-based supramolecular self-assemblies for drug delivery [J] . Bai Yang, An Na, Chen Di, Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides . 2020,第期

机译：体形β-环糊精的超分子自组装的舒适构造用于药物递送
4. Co-delivery of ETS1 siRNA and doxorubicin using supramolecular nanoparticles to overcome adriamycin resistance via downregulation of MDR1 transcription [C] . Min Wu, Yang Li, Xingang Liu, World biomaterials congress . 2016

机译：使用超分子纳米粒子共同递送ETS1 siRNA和阿霉素以通过下调MDR1转录克服对阿霉素的耐药性
5. Lock-Arm Supramolecular Ordering: A Self-Assembly Platform for Functional Organic Crystals [D] . Shveyd, Alexander K. 2011

机译：锁臂超分子订购：功能性有机晶体的自组装平台
6. Acid-Degradable Polymer-caged Lipoplex (PCL) Platform for siRNA Delivery: Facile Cellular Triggered Release of siRNA [O] . Bong Jin Hong, Anthony J. Chipre, SonBinh T. Nguyen -1

机译：用于siRNA递送的酸降解聚合物笼养脂质体（PCL）平台：siRNA的细胞触发触发释放
7. A supramolecular platform for controlling and optimizing molecular architectures of siRNA targeted delivery vehicles [O] . Yuting Wen, Hongzhen Bai, Jingling Zhu, 2020

机译：一种用于控制和优化siRNA靶向送货车的分子架构的超分子平台
8. Research Area 14.3 Microbiology and Biodegradation: Development of RNA-based Vectors for in vivo Delivery of siRNAs. [R] . TenOever, B. 2014

机译：研究领域14.3微生物学和生物降解：用于体内递送siRNa的基于RNa的载体的开发。

Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible-Light-Triggered Platform for Facile siRNA Delivery

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