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Glycomics: New Challenges and Opportunities in Regenerative Medicine

机译:糖化学:再生医学的新挑战和机遇

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摘要

Tissue engineering relies on the possibility to engineer cell microenvironments by means of bioactive materials, biochemical and physical stimuli in order to guide cell behaviour and to regenerate damaged tissue. Despite the relevance of glycan epitopes as signaling molecules, and the recent advances in glycomics, their use as biomolecular cues at the interface between materials and cells for the controlled stimulation of adhesion and differentiation processes for regenerative medicine applications is still limited. In this concept article we will briefly outline the basis and the impact on health and economics of regenerative medicine, together with the recent applications of the glycocode in tissue regeneration approaches.
机译:组织工程依赖于通过生物活性材料,生化和物理刺激来工程化细胞微环境的可能性,以指导细胞行为并再生受损的组织。尽管聚糖表位作为信号分子具有相关性,并且糖组学最近取得了进展,但是它们在材料和细胞之间的界面上作为生物分子线索用于受控刺激再生医学应用的粘附和分化过程仍然受到限制。在此概念文章中,我们将简要概述再生医学的基础及其对健康和经济的影响,以及糖典在组织再生方法中的最新应用。

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