• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Chemistry: A European journal >A Convenient Approach To Synthesize o-Carborane-Functionalized Phosphorescent Iridium(III) Complexes for Endocellular Hypoxia Imaging
【24h】

A Convenient Approach To Synthesize o-Carborane-Functionalized Phosphorescent Iridium(III) Complexes for Endocellular Hypoxia Imaging

机译：一种方便的方法合成邻碳硼烷功能化的磷铱（III）配合物用于细胞内缺氧成像

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The structure-property relationship of carborane-modified iridium(III) complexes was investigated. Firstly, an efficient approach for the synthesis of o-carborane-containing pyridine ligands a-f in high yields was developed by utilizing stable and cheap B10H10(Et4N)(2) as the starting material. By using these ligands, iridium(III) complexes I-VII were efficiently prepared. In combination with DFT calculations, the photophysical and electrochemical properties of these complexes were studied. The hydrophilic nido-o-carborane-based iridium(III) complex VII showed the highest phosphorescence efficiency (abs. phi P =0.48) among known water-soluble homoleptic cyclometalated iridium(III) complexes and long emission lifetime (=1.24s) in aqueous solution. Both of them are sensitive to O-2, and thus endocellular hypoxia imaging of complex VII was realized by time-resolved luminescence imaging (TRLI). This is the first example of applying TRLI in endocellular oxygen detection with a water-soluble nido-carborane functionalized iridium(III) complex.
机译：研究了碳硼烷修饰的铱（III）配合物的结构-性质关系。首先，通过利用稳定且廉价的B10H10（Et4N）（2）作为起始原料，开发了一种高产率地合成含邻甲烷的吡啶配体a-f的有效方法。通过使用这些配体，有效地制备了铱（III）配合物I-VII。结合DFT计算，研究了这些配合物的光物理和电化学性质。在已知的水溶性均化环金属化铱（III）络合物中，亲水性基于氨基-邻-甲碳烷的铱（III）络合物VII表现出最高的磷光效率（绝对phi P = 0.48），且在5,000℃下具有长发射寿命（= 1.24s）。水溶液。它们都对O-2敏感，因此通过时间分辨发光成像（TRLI）实现了复合物VII的胞内低氧成像。这是将TRLI与水溶性Nido-Carbane官能化的铱（III）配合物应用于细胞内氧气检测的第一个例子。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号