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首页> 外文期刊>Chemistry: A European journal >A Theranostic Agent Combining a Two-Photon-Absorbing Photosensitizer for Photodynamic Therapy and a Gadolinium(III) Complex for MRI Detection
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A Theranostic Agent Combining a Two-Photon-Absorbing Photosensitizer for Photodynamic Therapy and a Gadolinium(III) Complex for MRI Detection

机译：结合双光子吸收光敏剂用于光动力疗法和The（III）配合物用于MRI检测的治疗剂

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摘要

The convergent synthesis and characterization of a potential theranostic agent, [DPP-ZnP-GdDOTA](-), which combines a diketopyrrolopyrrole-porphyrin component DPP-ZnP as a two-photon photosensitizer for photodynamic therapy (PDT) with a gadolinium(III) DOTA complex as a magnetic resonance imaging probe, is presented. [DPP-ZnP-GdDOTA](-) has a remarkably high longitudinal water proton relaxivity (19.94mm(-1)s(-1) at 20MHz and 25 degrees C) for a monohydrated molecular system of this size. The Nuclear Magnetic Relaxation Dispersion (NMRD) profile is characteristic of slow rotation, related to the extended and rigid aromatic units integrated in the molecule and to self-aggregation occurring in aqueous solution. The two-photon properties were examined and large two-photon absorption cross-sections around 1000GM were determined between 910 and 940nm in DCM with 1% pyridine and in DMSO. Furthermore, the new conjugate was able to generate singlet oxygen, with quantum yield of 0.42 and 0.68 in DCM with 1% pyridine and DMSO, respectively. Cellular studies were also performed. The [DPP-ZnP-GdDOTA](-) conjugate demonstrated low dark toxicity and was able to induce high one-photon and moderate two-photon phototoxicity on cancer cells.
机译：潜在治疗药物[DPP-ZnP-GdDOTA]（-）的聚合合成和表征，该化合物结合了二酮吡咯并吡咯-卟啉组分DPP-ZnP作为用于光动力疗法（PDT）的二光子光敏剂和ado（III）介绍了DOTA复合物作为磁共振成像探针。 [DPP-ZnP-GdDOTA]（-）对于这种大小的一水合分子系统，具有很高的纵向水质子弛豫性（在20MHz和25摄氏度下为19.94mm（-1）s（-1））。核磁弛豫分散度（NMRD）曲线具有慢速旋转的特征，与分子中整合的延伸和刚性芳族单元以及在水溶液中发生的自聚集有关。在具有1％吡啶的DCM和DMSO中，检查了两个光子的性质，并确定了910nm至940nm之间的大的1000GM附近的两个光子吸收截面。此外，新的共轭物能够产生单线态氧，在含1％吡啶和DMSO的DCM中，量子产率分别为0.42和0.68。还进行了细胞研究。 [DPP-ZnP-GdDOTA]（-）偶联物表现出低的暗毒性，并且能够诱导癌细胞具有较高的单光子和中度双光子光毒性。

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