Cascade Mn-Mediated gamma-Alkylation/oxa-Michael Addition of Enones with 1,3-Dicarbonyls

Liu Xiaoguang; Chen Xiaohong; Mohr Justin T.

首页> 外文期刊>Chemistry: A European journal >Cascade Mn-Mediated gamma-Alkylation/oxa-Michael Addition of Enones with 1,3-Dicarbonyls

【24h】

Cascade Mn-Mediated gamma-Alkylation/oxa-Michael Addition of Enones with 1,3-Dicarbonyls

机译：Mn与1,3-二羰基酮的级联Mn介导的γ-烷基化/ oxa-Michael加成

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A radical-based strategy for regioselective -C-C bond formation/oxa-conjugate addition, forming the tetrahydrobenzofuran core common to many bioactive natural products is described. The technique utilizes readily available enone derivatives and 1,3-dicarbonyl compounds as coupling partners in an oxidative formal [3+2] cycloaddition mediated by Mn-III. The transformation delivers polycyclic products in good yields and proceeds with complete regiocontrol and excellent stereoselectivity. Sterically encumbered substrates are notably well-tolerated and bond formation occurs readily to form neopentyl and all-carbon quaternary centers in good yields. Several stereo- and chemoselective transformations of the products are described.

机译：描述了基于自由基的区域选择性-C-C键形成/氧杂-共轭加成的策略，形成了许多生物活性天然产物共有的四氢苯并呋喃核。该技术利用容易得到的烯酮衍生物和1,3-二羰基化合物作为由Mn-III介导的氧化形式[3 + 2]环加成反应中的偶联伙伴。该转化可提供高收率的多环产物，并具有完整的区域控制和出色的立体选择性。立体阻碍的底物具有良好的耐受性，并且容易形成键，从而以高收率形成新戊基和全碳季中心。描述了产物的几种立体和化学选择性转化。

著录项

来源
《Chemistry: A European journal》 |2016年第7期|共4页
作者
Liu Xiaoguang; Chen Xiaohong; Mohr Justin T.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词
manganese; oxidation; radicals; regioselectivity; stereoselectivity;

机译：锰;氧化;自由基;区域选择性;立体选择性;

相似文献

外文文献
中文文献
专利

1. Cascade Mn-Mediated gamma-Alkylation/oxa-Michael Addition of Enones with 1,3-Dicarbonyls [J] . Liu Xiaoguang, Chen Xiaohong, Mohr Justin T. Chemistry: A European journal . 2016,第7期

机译：Mn与1,3-二羰基酮的级联Mn介导的γ-烷基化/ oxa-Michael加成
2. Organocatalytic, Chemoselective Hydrophosphenylation/oxa-Michael Addition Cascade toward Diastereo- and Enantioenriched 1,3-Dihydroisobenzofuryl Phosphonates [J] . Hazra Gurupada, Pratap Shiv, Ghorai Prasanta The Journal of Organic Chemistry . 2018,第17期

机译：有机催化，化学选择性疏水磷酸盐/ Oxa-michael加入级联朝向非对映的1,3-二羟基异脲膦酸盐
3. Cascade Michael Addition/Cycloketalization of Cyclic 1,3-Dicarbonyl Compounds:Important Role of the Tethered Alcohol of α,β- Unsaturated Carbonyl Compounds on Reaction Rate and Regioselectivity [J] . Hongliang Yao, Liyan Song, Yuan Liu, The Journal of Organic Chemistry . 2014,第18期

机译：环状1,3-二羰基化合物的级联Michael加成/环化反应：α，β-不饱和羰基化合物的束缚醇对反应速率和区域选择性的重要作用
4. Efficient Synthesis of 1,3-Diketones by the RuHCl(CO)(PPh_3)_3-Catalyzed Addition of Aldehydes to Enones [C] . Sohei Omura, Takashi Doi, Satoshi Minamino Symposium on Organometallic Chemistry . 2006

机译：用RuHCl（CO）（PPH_3）_3催化添加醛的1,3-二酮合成1,3-二酮
5. The nickel and palladiumallyl chemistry of enals, enones, and enal-derived 2-alkenyl-1,3-dioxolan-4-ones. [D] . Johnson, John Robert. 1991

机译：enals，enones和enal衍生的2-alkenyl-1,3-dioxolan-4-ones的镍和钯烯丙基化学。
6. Rh(iii)-catalyzed diastereoselective C–H bond addition/cyclization cascade of enone tethered aldehydes [O] . Jeffrey A. Boerth, Jonathan A. Ellman 2016

机译：Rh（iii）催化的烯键式醛的非对映选择性C–H键加成/环化级联
7. Enantioselective, Organocatalytic, Dissymmetric 1,4- and 1,2-Addition of Malononitrile to a Keto-bisenone Followed by an Oxa-Michael Addition Cascade [O] . -1

机译：对Keto-Bisenone的映选择性，有机催化，不对称的1,4-和1,2-加入丙二腈，然后加入牛肉 - 迈克尔加成级联

Cascade Mn-Mediated gamma-Alkylation/oxa-Michael Addition of Enones with 1,3-Dicarbonyls

摘要

著录项

相似文献

相关主题

期刊订阅