A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes

De Rache Aurore; Gueddouda Nassima Meriem; Bourdoncle Anne; Hommes Paul; Reissig Hans-Ulrich; Mergny Jean-Louis

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A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes

机译：灵活的吡啶吡啶衍生物与G-四链体相互作用

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G-quadruplexes formed by nucleic acids are implicated in pathologies ranging from cancers to neurodegenerative diseases. We evaluated interactions of 29 bi- and terpyridine derivatives with G-quadruplexes and duplexes. FRET-melting, circular dichroism, and H-1 NMR spectroscopy showed that one terpyridine derivative interacted very selectively with G-quadruplexes. This G-quadruplex ligand inhibited helicase activity and should influence G-quadruplex-related biological processes.

机译：由核酸形成的G-四链体涉及从癌症到神经退行性疾病的各种病理学。我们评估了29个联吡啶和三联吡啶衍生物与G-四链体和双链体的相互作用。 FRET熔解，圆二色性和H-1 NMR光谱表明，一种三联吡啶衍生物与G-四链体非常选择性地相互作用。这种G四联体配体抑制解旋酶活性，并应影响G四联体相关的生物过程。

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来源
《Chemistry: A European journal》 |2016年第36期|共4页
作者
De Rache Aurore; Gueddouda Nassima Meriem; Bourdoncle Anne; Hommes Paul; Reissig Hans-Ulrich; Mergny Jean-Louis;
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正文语种 eng
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关键词
bipyridine; G4 ligand; G-quadruplex; helicase; terpyridine;

机译：联吡啶;G4配体;G-四联体;解旋酶;三联吡啶;

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1. A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes [J] . De Rache Aurore, Gueddouda Nassima Meriem, Bourdoncle Anne, Chemistry: A European journal . 2016,第36期

机译：灵活的吡啶吡啶衍生物与G-四链体相互作用
2. A series of terpyridine containing flexible amino diethylacetate derivatives with large two-photon action cross-sections for effective mitochondrial imaging in living liver cancerous cells [J] . Ran Jia, Yingying Zhu, Lei Hu, Spectrochimica acta, Part A. Molecular and biomolecular spectroscopy . 2018,第期

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3. Lattice interactions of terpyridines and their derivatives - free terpyridines and their protonated forms [J] . Lee Young Hoon, Kim Jee Young, Kim Yang, CrystEngComm . 2016,第41期

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4. A Series of Ln(NO_3)_3(4'-(4-Bromophenyl)-2,2':6',2"-Terpyridine) Lanthanide Derivatives [C] . Piedraescrita Gallardo, Elisa Abas, Alicia Buceta, International Conference on Solid Compounds of Transition Elements . 2017

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6. Directing 2D-Coordination Networks: Combined Effects of a Conformationally Flexible 32′:6′3″-Terpyridine and Chain Length Variation in 4′-(4-n-Alkyloxyphenyl) Substituents [O] . Dalila Rocco, Alessandro Prescimone, Edwin C. Constable, 2020

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7. Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes [O] . Ruby J Roach, Miguel Garavís, Carlos González, 2019

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8. Interactive Effects of Aromatic Hydrocarbons, Their Derivatives, and Heavy Metals in Marine Fish [R] . Gruger, E. H. , Hawkes, J. W. , Malins, D. C. 1981

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A Flexible Terpyridine Derivative Interacts Specifically with G-Quadruplexes

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