Cobalt-Catalyzed C(sp(2))-H Methylation by using Dicumyl Peroxide as both the Methylating Reagent and Hydrogen Acceptor

Li Qun; Li Yanrong; Hu Weipeng; Hu Renjian; Li Guigen; Lu Hongjian

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Cobalt-Catalyzed C(sp(2))-H Methylation by using Dicumyl Peroxide as both the Methylating Reagent and Hydrogen Acceptor

机译：通过使用过氧化二枯基作为甲基化试剂和氢受体的钴催化的C（sp（2））-H甲基化

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The first cobalt-catalyzed direct methylation of a C(sp(2))-H bond using dicumyl peroxide (DCP) as both the methylating reagent and hydrogen acceptor has been established. The reaction proceeded without the use of any additives, and was proven to be applicable to various amides bearing a 2-pyridinylisopropyl (PIP) directing group, providing an efficient access to o-methyl aryl amides with high functional-group tolerance. Preliminary mechanistic studies suggest a radical process would be involved in the catalytic process.

机译：已经建立了使用二枯基过氧化物（DCP）作为甲基化试剂和氢受体的钴（C（sp（2））-H键的首次钴催化直接甲基化。反应在不使用任何添加剂的情况下进行，并被证明可用于带有2-吡啶基异丙基（PIP）导向基团的各种酰胺，从而可以有效地获得具有高官能团耐受性的邻甲基芳基酰胺。初步的机理研究表明，催化过程将涉及自由基过程。

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《Chemistry: A European journal》 |2016年第35期|共4页
作者
Li Qun; Li Yanrong; Hu Weipeng; Hu Renjian; Li Guigen; Lu Hongjian;
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正文语种 eng
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关键词
amides; C-H functionalization; cobalt; methylation; peroxide;

机译：酰胺;C-H官能化;钴;甲基化;过氧化物;

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1. Cobalt-Catalyzed C(sp(2))-H Methylation by using Dicumyl Peroxide as both the Methylating Reagent and Hydrogen Acceptor [J] . Li Qun, Li Yanrong, Hu Weipeng, Chemistry: A European journal . 2016,第35期

机译：通过使用过氧化二枯基作为甲基化试剂和氢受体的钴催化的C（sp（2））-H甲基化
2. Dicumyl Peroxide as a Methylating Reagent in the Ni-Catalyzed Methylation of Ortho C-H Bonds in Aromatic Amides [J] . Kubo Teruhiko, Chatani Naoto Organic letters . 2016,第7期

机译：Ni催化的芳酰胺中邻位C-H键的甲基化反应中过氧化二枯基的甲基化反应
3. Copper-catalyzed N-methylation of amides and O-methylation of carboxylic acids by using peroxides as the methylating reagents [J] . Xia Q., Liu X., Zhang Y., Organic letters . 2013,第13期

机译：用过氧化物作为甲基化试剂，铜催化酰胺的N-甲基化和羧酸的O-甲基化
4. Crosslinking of Poly (propylene carbonate) by Peroxide Crosslinking Agent Dicumyl Peroxide (DCP) [C] . WANG X L, MENG Y Z, LI R K Y 中山大学学报（自然科学版） . 2006

机译：过氧化物交联剂二枯基过氧化物（DCP）交联聚碳酸亚丙酯
5. Activation of Yap1 by hydrogen peroxide or cysteine thiol-reactive Michael acceptors leads to selective adaptive gene responses in the yeast Saccharomyces cerevisiae [D] . Ouyang, Xiaoguang 2010

机译：过氧化氢或半胱氨酸硫醇反应性迈克尔受体激活Yap1导致啤酒酵母中的选择性适应性基因反应。
6. Cobalt-Catalyzed Stereoretentive Hydrogen Isotope Exchange of C(sp3)−H Bonds [O] . W. Neil Palmer, Paul J. Chirik -1

机译：钴催化的C（sp3）-H键的立体定向氢同位素交换
7. Cobalt-Catalyzed Switchable Intramolecular Thioenolization/CH Thiolation and C(sp2)H/C(sp3)H Dehydrogenative Coupling [O] . -1

机译：钴催化可切换分子内硫代酚/ Ch硫醇化和C（SP2）H / C（SP3）H脱氢偶联

Cobalt-Catalyzed C(sp(2))-H Methylation by using Dicumyl Peroxide as both the Methylating Reagent and Hydrogen Acceptor

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