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首页> 外文期刊>Chemistry: A European journal >Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs
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Syntheses of Platinum-Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs

机译：铂-舒林酸复合物及其纳米粒子作为靶向抗癌药物的合成

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摘要

Platinum(II)-sulindac complexes [{(2)-C5H4SN(O)}Pt(DMSO){O(C=O)Sulindac}], [{(2)-C5H4SN(O)}PtCl{(S=O)Sulindac}], [{(2)-C5H4SN(O)}PtCl{(S=O)Sulindac-succinimide}], and [{(2)-C5H4SN(O)}PtCl{(S=O)Sulindac-thymidine}] were synthesized that exhibited IC50 values of 2.9-4.8m against human oral cancer cells OECM1. The poly(lactic-co-glycolic acid) (PLGA) encapsulated [{(2)-C5H4SN(O)}PtCl{(S=O)Sulindac}] also showed cytotoxic activity although less potent than the pristine species.
机译：铂（II）-舒林酸复合物[{（2）-C5H4SN（O）} Pt（DMSO）{O（C = O）舒林酸}]，[{（2-C5H4SN（O）} PtCl {（S = O ）Sulindac}]，[{（（2）-C5H4SN（O）} PtCl {（S = O）Sulindac-succinimide}]和[{（2-C5H4SN（O）} PtCl {（S = O）Sulindac-合成了对人口腔癌细胞OECM1的IC50值为2.9-4.8m的胸苷。封装的聚乳酸-乙醇酸（PLGA）[{（2）-C5H4SN（O）} PtCl {（S = O）Sulindac}]也显示出细胞毒活性，尽管效力不如原始物种。

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