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首页> 外文期刊>Chemistry Letters >Palladium-doped Nanogold Microspheres as Nanocatalysts for Enzyme-free Electrochemical Immunosensing of Low-abundance Protein
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Palladium-doped Nanogold Microspheres as Nanocatalysts for Enzyme-free Electrochemical Immunosensing of Low-abundance Protein

机译：钯掺杂纳米金微球作为纳米催化剂用于低丰度蛋白的无酶电化学免疫传感

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摘要

Palladium-doped nanogold microspheres were for the first time utilized as nanocatalysts and peroxidase mimics for development of enzyme-free electrochemical immunosensing with sensitivity enhancement. Palladium (Pd) nanomaterials, due to their highly efficient catalytic properties for facilitating the reaction of both oxygen reduction and hydrogen oxidation, have been widely applied in fuel cells, photocatalytic water splitting into hydrogen, and chemical catalysis.1 Recent reports have demonstrated that Pd nanostructures could be used as peroxidase-like catalysts for H2O2 reduction.2 However, pure palladium nanostructures have no ability to directly conjugate with biomolecules. In contrast, nanocomposites differ from conventional composite materials due to the exceptionally high surface-to-volume ratio of the reinforcing phase and/or exceptionally high aspect ratios.3 The properties of nanocomposites depend not only on the properties of their individual parents but also on their morphology and interfacial characteristics. Colloidal gold is an ideal host in nanotechnology due to its inherent merits, such as easy preparation, good biocompatibility, and conjugation capacity with proteins.4 In this regard, our motivation herein is to synthesize gold-palladium hybrid nanostructures (AuPd) with catalytic activity for development of an enzyme-free electrochemical immunoassay (Scheme 1).
机译：掺杂钯的纳米金微球首次用作纳米催化剂和过氧化物酶模拟物，用于开发无酶电化学免疫反应，并提高了灵敏度。钯（Pd）纳米材料由于具有促进氧还原和氢氧化反应的高效催化性能，因此已广泛应用于燃料电池，光催化水分解为氢和化学催化的研究中。1最近的报道表明，钯（Pd）纳米结构可以用作过氧化物酶样的催化剂来减少H2O2。2但是，纯钯纳米结构没有直接与生物分子结合的能力。相反，纳米复合材料由于增强相的极高的表面体积比和/或极高的长径比而不同于传统的复合材料。3纳米复合材料的性能不仅取决于其各自母体的性能，而且取决于它们的形态和界面特征。胶体金具有内在的优点，例如易于制备，良好的生物相容性以及与蛋白质的结合能力，因此是纳米技术的理想宿主。4在这方面，我们的动机是合成具有催化活性的金-钯杂化纳米结构（AuPd）。用于开发无酶电化学免疫测定（方案1）。

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