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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >STEREOCHEMISTRY OF PEPTIDES AND POLYPEPTIDES CONTAINING OMEGA AMINO ACIDS [Review]
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STEREOCHEMISTRY OF PEPTIDES AND POLYPEPTIDES CONTAINING OMEGA AMINO ACIDS [Review]

机译：含OMEGA氨基酸的多肽和多肽的立体化学[综述]

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摘要

The omega amino acids have a larger degree of conformational variability than the alpha amino acids, leading to a greater diversity of backbone structures in peptides and polypeptides. The synthetic accessibility of chiral beta-amino acids and the recent observation of novel helical folds in oligomers of cyclic beta-amino acids has led to renewed interest in the stereochemistry of omega-amino acid containing peptides. This review focuses on the conformational characteristics of the polymethylene chain in omega-amino acid segments and surveys structural features in peptides established by X-ray diffraction. The literature on polymers of achiral omega-amino acids (nylon derivatives) and chiral, substituted derivatives derived from trifunctional alpha-amino acids, reveals that while sheet-like, intermolecular hydrogen bonded structures are formed by the former, folded helices appear favoured by the latter. omega-Amino acids promise to expand the repertoire of peptide folds. [References: 91]
机译：ω氨基酸比α氨基酸具有更大程度的构象变异性，从而导致肽和多肽中主链结构的多样性更大。手性β-氨基酸的合成可及性以及最近在环状β-氨基酸的寡聚体中发现新的螺旋折叠的研究引起了人们对含ω-氨基酸的肽的立体化学的新兴趣。这项审查侧重于ω-氨基酸片段中的聚亚甲基链的构象特征，并调查了通过X射线衍射建立的肽的结构特征。关于非手性ω-氨基酸（尼龙衍生物）和衍生自三官能α-氨基酸的手性取代衍生物的聚合物的文献显示，尽管前者形成了片状分子间氢键结构，但折叠螺旋似乎受到了它们的青睐。后者。 ω-氨基酸有望扩大肽折叠的库。 [参考：91]

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