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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >The legacy of G. N. Ramachandran and the development of structural biology in India
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The legacy of G. N. Ramachandran and the development of structural biology in India

机译：G. N. Ramachandran的遗产和印度结构生物学的发展

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G. N. Ramachandran is among the founding fathers of structural molecular biology. He made pioneering contributions in computational biology, modelling and what we now call bioinformatics. The triple helical coiled coil structure of collagen proposed by him forms the basis of much of collagen research at the molecular level. The Ramachandran map remains the simplest descriptor and tool for validation of protein structures. He has left his imprint on almost all aspects of biomolecular conformation. His contributions in the area of theoretical crystallography have been outstanding. His legacy has provided inspiration for the further development of structural biology in India. After a pause, computational biology and bioinformatics are in a resurgent phase. One of the two schools established by Ramachandran pioneered the development of macromolecular crystallography, which has now grown into an important component of modern biological research in India. Macromolecular NMR studies in the country are presently gathering momentum. Structural biology in India is now poised to again approach heights of the kind that Ramachandran conquered more than a generation ago.
机译：G. N. Ramachandran是结构分子生物学的创始人之一。他在计算生物学，建模以及现在称为生物信息学的领域做出了开创性的贡献。他提出的胶原蛋白的三重螺旋卷曲螺旋结构在分子水平上构成了许多胶原蛋白研究的基础。 Ramachandran图谱仍然是用于验证蛋白质结构的最简单的描述符和工具。他在生物分子构象的几乎所有方面都留下了烙印。他在理论晶体学领域的贡献是杰出的。他的遗产为印度结构生物学的进一步发展提供了灵感。片刻之后，计算生物学和生物信息学处于复苏阶段。拉马尚德兰（Ramachandran）建立的两所学校中的一所开创了大分子晶体学发展的先河，现已发展成为印度现代生物学研究的重要组成部分。该国的大分子NMR研究目前正在蓬勃发展。现在，印度的结构生物学已准备好再次超越拉马尚德人征服的高度。

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