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首页> 外文期刊>Acta Horticulturae >Xanthohumol from hops prevents hormone-dependent tumourigenesis in vitro and in vivo.
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Xanthohumol from hops prevents hormone-dependent tumourigenesis in vitro and in vivo.

机译：啤酒花中的黄腐酚可在体内外阻止激素依赖性肿瘤的发生。

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Since the 1990s, interest in health-promoting effects of xanthohumol (XN) has increased constantly. This manuscript will review some of the published literature as well as novel findings on XN. In 2002, we identified XN as a potent cancer chemopreventive agent acting by multiple mechanisms relevant for the prevention of carcinogenesis. Although hops is commonly linked with phytoestrogenic effects, we identified XN as a pure estrogen antagonist. Interestingly, XN may also reduce the generation of estrogens by inhibition of the enzymatic activity of aromatase, which converts testosterone to estrogen. Anti-estrogenic effects of XN (100 mg/kg body weight/day) were confirmed in vivo in an uterotrophy assay with prepubertal rats. In two fertility studies, long-term treatment with XN did not cause any adverse effect on female reproduction and on the development of offspring when given either for four weeks prior to or during mating, gestation and nursing. Novel data indicate that XN (100 mg/kg body weight/day in drinking water) prevents dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in rats when given nine days prior to and for 16 weeks after the carcinogen. Tumour incidence was not influenced by XN treatment, but XN significantly reduced tumour multiplicity and tumour burden. XN (1000 mg/kg body weight/day injected subcutaneously for 14 days) also significantly reduced the growth of human breast cancer xenotransplants in immune-compromised mice and reduced tumour-induced neovascularization. Overall, these data demonstrate breast cancer preventive efficacy of XN. Multiple mechanisms, including modulation of DMBA metabolism, anti-estrogenic, anti-proliferative and anti-angiogenic activities may account for these effects and are under further investigation.
机译：自1990年代以来，对黄腐酚（XN）的健康促进作用的兴趣不断增加。该手稿将回顾一些已发表的文献以及有关XN的新发现。在2002年，我们确定XN是一种有效的癌症化学预防剂，它通过与预防癌变有关的多种机制起作用。尽管啤酒花通常与植物雌激素作用有关，但我们将XN鉴定为纯雌激素拮抗剂。有趣的是，XN还可以通过抑制芳香化酶的酶活性来减少雌激素的产生，芳香化酶将睾丸激素转化为雌激素。 XN（100 mg / kg体重/天）的抗雌激素作用已在青春期前大鼠的子宫营养试验中得到证实。在两项生育力研究中，在交配，妊娠和哺乳前或哺乳期四周内给予XN长期治疗，对女性生殖和后代发育均无任何不利影响。新颖的数据表明，XN（饮用水中每天100 mg / kg体重/天）在给药前9天和给药16周可预防二甲基苯并[蒽]蒽（DMBA）诱导的大鼠乳腺癌致癌作用。之后致癌。肿瘤的发生率不受XN治疗的影响，但XN显着降低了肿瘤的多重性和肿瘤负担。 XN（1000 mg / kg体重/天，皮下注射14天）还显着降低了免疫受损小鼠中人乳腺癌异种移植的生长，并减少了肿瘤引起的新血管形成。总体而言，这些数据证明了XN的乳腺癌预防功效。多种机制，包括DMBA代谢的调节，抗雌激素，抗增殖和抗血管生成活性，可能是造成这些影响的原因，目前正在进一步研究中。

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