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首页> 外文期刊>Acta Horticulturae >Antimicrobial activity of in situ forming gel comprising cork tree seed extract.
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Antimicrobial activity of in situ forming gel comprising cork tree seed extract.

机译：包含软木树种子提取物的原位形成凝胶的抗菌活性。

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摘要

Cork tree (Sonneratia caseolaris) is a plant in the family of Sonneratiaceae whose extract has been reported for the traditional use as an astringent and an antiseptic. The methanolic seed extract of cork tree was employed as the active compound in the in situ forming gel containing 30% Eudragit RS in N-methyl pyrrolidone. The prepared gel exhibited the in situ formimg gel properties. The anitimicrobial activity was tested with agar diffusion method using Staphylococcus aureus ATCC 6538, Escherichia coli ATCC 8740, Candida albicans ATCC 17110, Streptococcus mutans ATCC 27175 and anaerobic bacteria from oral cavity as tested microbes. The obtained gel could inhibit all tested microbes. The release of three markers (gallic acid, luteolin glycoside and luteolin) from 10% w/w seed extract gel was performed using dialysis tube method in phosphate buffer pH 6.8. The released amount of three markers was analyzed simultaneously with HPLC method. Gallic acid and luteolin, respectively, were rapidly released in the initial stage and gradually released for 720 min. Luteolin glycoside started to release at 480 min. and lesser amount was released into the medium at 720 min. In situ forming gel comprising cork tree seed extract exhibited the potential dosage form to deliver the active compound from natural product and show antimicrobial activity.
机译：软木（Sonneratia caseolaris）是Sonneratiaceae家族的一种植物，据报道其提取物传统用作收敛剂和防腐剂。在含有30％Eudragit RS在N-甲基吡咯烷酮中的原位形成凝胶中，用软木树的甲醇种子提取物作为活性化合物。制备的凝胶表现出原位形式的凝胶性质。使用金黄色葡萄球菌ATCC 6538，大肠杆菌ATCC 8740，白色念珠菌ATCC 17110，变形链球菌ATCC 27175和来自口腔的厌氧细菌作为测试微生物，采用琼脂扩散法测试其抗菌活性。所获得的凝胶可以抑制所有测试的微生物。使用透析管法在pH 6.8的磷酸盐缓冲液中从10％w / w种子提取物凝胶中释放出三种标记物（没食子酸，木犀草素糖苷和木犀草素）。用HPLC法同时分析了三种标志物的释放量。没食子酸和木犀草素分别在初始阶段迅速释放并逐渐释放720分钟。木犀草素苷在480分钟时开始释放。并且在720分钟时将较少量释放到培养基中。包含软木树种子提取物的原位形成凝胶显示出潜在的剂型，可以从天然产物中递送活性化合物并显示出抗菌活性。

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