...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>ACS applied materials & interfaces >Electrochemically Controlled Drug-Mimicking Protein Release from Iron-Alginate Thin-Films Associated with an Electrode
【24h】

Electrochemically Controlled Drug-Mimicking Protein Release from Iron-Alginate Thin-Films Associated with an Electrode

机译：从与电极相关的海藻酸铁薄膜中释放电化学控制的模拟药物蛋白质

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Novel biocompatible hybrid-material composed of iron-ion-cross-linked alginate with embedded protein molecules has been designed for the signal-triggered drug release. Electrochemically controlled oxidation of Fe~(2+) ions in the presence of soluble natural alginate polymer and drug-mimicking protein (bovine serum albumin, BSA) results in the formation of an alginate-based thin-film cross-linked by Fe-~(3+) ions at the electrode interface with the entrapped protein. The electrochemically generated composite thin-film was characterized by electrochemistry and atomic force microscopy (AFM). Preliminary experiments demonstrated that the electrochemically controlled deposition of the protein-containing thin-film can be performed at microscale using scanning electrochemical microscopy (SECM) as the deposition tool producing polymer-patterned spots potentially containing various entrapped drugs. Application of reductive potentials on the modified electrode produced Fe~(2+) cations which do not keep complexation with alginate, thus resulting in the electrochemically triggered thin-film dissolution and the protein release. Different experimental parameters, such as the film-deposition time, concentrations of compounds and applied potentials, were varied in order to demonstrate that the electrodepositon and electrodissolution of the alginate composite film can be tuned to the optimum performance. A statistical modeling technique was applied to find optimal conditions for the formation of the composite thin-film for the maximal encapsulation and release of the drug-mimicking protein at the lowest possible potential.
机译：由铁离子交联的藻酸盐与包埋的蛋白质分子组成的新型生物相容性杂化材料已被设计用于信号触发的药物释放。 Fe〜（2+）离子在可溶性天然藻酸盐聚合物和模拟药物蛋白（牛血清白蛋白，BSA）存在下的电化学控制氧化作用，导致形成以Fe-〜交联的藻酸盐基薄膜电极上的（3+）离子与被捕获的蛋白质相互作用。电化学产生的复合薄膜通过电化学和原子力显微镜（AFM）表征。初步实验表明，可以使用扫描电化学显微镜（SECM）作为沉积工具，在微尺度上对含蛋白质的薄膜进行电化学控制的沉积，以产生可能包含各种截留药物的聚合物构图斑点。在修饰的电极上施加还原电势会产生Fe〜（2+）阳离子，这些阳离子不会与藻酸盐保持络合，从而导致电化学触发的薄膜溶解和蛋白质释放。改变不同的实验参数，例如膜沉积时间，化合物的浓度和施加的电势，以证明藻酸盐复合膜的电沉积和电溶解可以调节到最佳性能。应用统计建模技术来找到形成复合薄膜的最佳条件，以便在可能的最低电位下最大程度地包封和释放模拟药物的蛋白质。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号