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首页> 外文期刊>ACS applied materials & interfaces >Nanoparticle Targeting CD44-Positive Cancer Cells for Site-Specific Drug Delivery in Prostate Cancer Therapy
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Nanoparticle Targeting CD44-Positive Cancer Cells for Site-Specific Drug Delivery in Prostate Cancer Therapy

机译：靶向CD44阳性癌细胞的纳米颗粒用于前列腺癌治疗中的特定部位药物递送。

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摘要

Prostate cancer is one of the leading causes of cancer death in adult men and is a multistage disease with therapeutic challenges of local recurrent advanced tumors and distant metastatic disease. CD44 is a multifunctional and multistructural cell surface glycoprotein that is involved in cell-cell interactions, cell proliferation, and cell migration. In the study, we produced negatively charged and biocompatible hyaluronic acid-based nanoparticles as a therapeutic system for targeting CD44-positive cancer cells. Subsequently, we confirmed the delivery of bioactive epigallocatechin-3-gallate and site-specific inhibition of prostate tumor growth. In this study, hyaluronic acid based nanoparticles successfully encapsulated epigallocatechin-3-gallate and were efficiently internalized into cancer cells via CD44 ligand receptor recognition, induced cell cycle arrest at G2/M phase, and inhibited prostate cancer cell growth. Furthermore, in vivo assays indicated that these nanoparticles specifically bind CD44 receptors and increase apoptosis of cancer cells, leading to significant decreases in prostate tumor activity and tumor tissue inflammation.
机译：前列腺癌是成年男性癌症死亡的主要原因之一，是一种多阶段疾病，其治疗挑战是局部复发性晚期肿瘤和远处转移性疾病。 CD44是一种多功能，多结构的细胞表面糖蛋白，与细胞-细胞相互作用，细胞增殖和细胞迁移有关。在这项研究中，我们生产了带负电荷且生物相容性的透明质酸纳米颗粒，作为靶向CD44阳性癌细胞的治疗系统。随后，我们证实了具有生物活性的epigallocatechin-3-gallate的传递和对前列腺肿瘤生长的位点特异性抑制。在这项研究中，透明质酸基纳米颗粒成功地封装了epigallocatechin-3-gallate，并通过CD44配体受体识别被有效地内化到癌细胞中，诱导细胞周期停滞在G2 / M期，并抑制了前列腺癌细胞的生长。此外，体内测定表明这些纳米颗粒特异性结合CD44受体并增加癌细胞的凋亡，从而导致前列腺肿瘤活性和肿瘤组织炎症的显着降低。

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