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首页> 外文期刊>ACS applied materials & interfaces >Liquid-Infused Poly(styrene-b-isobutylene-b-styrene) Microfiber Coating Prevents Bacterial Attachment and Thrombosis
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Liquid-Infused Poly(styrene-b-isobutylene-b-styrene) Microfiber Coating Prevents Bacterial Attachment and Thrombosis

机译：液体注入的聚（苯乙烯-b-异丁烯-b-苯乙烯）微纤维涂层可防止细菌附着和血栓形成

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摘要

Infection and thrombosis associated with medical implants cause significant morbidity and mortality worldwide. As we know, current technologies to prevent infection and thrombosis may cause severe side effects. To overcome these complications without using antimicrobial and anticoagulant drugs, we attempt to prepare a liquid-infused poly(styrene-b-isobutylene-b-styrene) (SIBS) microfiber coating, which can be directly coated onto medical devices. Notably, the SIBS microfiber was fabricated through solution blow spinning. Compared to electrospinning, the solution blow spinning method is faster and less expensive, and it is easy to spray fibers onto different targets. The lubricating liquids then wick into and strongly adhere the microfiber coating. These slippery coatings can effectively suppress blood cell adhesion, reduce hemolysis, and inhibit blood coagulation in vitro. In addition, Pseudomonas aeruginosa (P. aeruginosa) on the lubricant infused coatings slides readily, and no visible residue is left after tilting. We furthermore confirm that the lubricants have no effects on bacterial growth. The slippery coatings are also not cytotoxic to L929 cells. This liquid-infused SIBS microfiber coating could reduce the infection and thrombosis of medical devices, thus benefiting human health.
机译：与医学植入物相关的感染和血栓形成在全世界范围内引起很大的发病率和死亡率。众所周知，目前防止感染和血栓形成的技术可能会导致严重的副作用。为了在不使用抗微生物和抗凝药的情况下克服这些并发症，我们尝试制备一种液体注入的聚（苯乙烯-b-异丁烯-b-苯乙烯）（SIBS）微纤维涂层，该涂层可以直接涂覆在医疗设备上。值得注意的是，SIBS超细纤维是通过溶液吹纺法制造的。与静电纺丝相比，溶液吹纺法更快，更便宜，并且易于将纤维喷涂到不同的目标上。然后，润滑液体芯吸并牢固地粘附在微纤维涂层上。这些光滑的涂层可以有效地抑制血细胞粘附，减少溶血，并在体外抑制凝血。另外，注入润滑剂的涂层上的铜绿假单胞菌（P.铜绿假单胞菌）容易滑动，并且倾斜后没有留下可见的残留物。我们进一步证实润滑剂对细菌的生长没有影响。光滑的涂层对L929细胞也没有细胞毒性。这种液体注入的SIBS超细纤维涂层可以减少医疗器械的感染和血栓形成，从而有益于人体健康。

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