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首页> 外文期刊>ACS applied materials & interfaces >Injectable Self-Assembled Dipeptide-Based Nanocarriers for Tumor Delivery and Effective In Vivo Photodynamic Therapy
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Injectable Self-Assembled Dipeptide-Based Nanocarriers for Tumor Delivery and Effective In Vivo Photodynamic Therapy

机译：可注射的自组装的基于二肽的纳米载体用于肿瘤递送和有效的体内光动力疗法

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摘要

Self-assembling peptide-based materials are playing an important role in fabricating drug delivery carriers; however, they are often limited by several challenges, such as precise structure modulation, desirable nanoscale size, and sufficient circulation lifetime in the body. To address this issue, herein one type of injectable dipeptide-based nanocarriers with well modulated size and structure has been developed by adjusting glutaraldehyde (GA)-assisted cationic dipeptide (CDP) assembly. After loading a model photosensitive drug (Ce6) and further decorating CDP nanoparticles (NPs) with heparin polymers (Hep), the desired dipeptide-based NPs are achieved with an average diameter of 100 rim and surface charge of -25 mV, which are favorable for the enhanced permeability and retention effects. Significantly, the dipeptide-based NPs with Ce6 loading have a longer circulation lifetime against opsonization than free Ce6 solution, and subsequently, they achieve the best anticancer efficiency in vivo. They do not cause body weight loss or induce bad immune activation in organs, implying good biosafety of the designed carriers. Taken together, dipeptide-based delivery carriers through GA-assisted assembly may provide a new alternative for developing precisely controlled nanostructures toward effective antitumor therapy.
机译：自组装的基于肽的材料在制备药物输送载体中起着重要作用。然而，它们通常受到一些挑战的限制，例如精确的结构调节，所需的纳米级尺寸以及体内足够的循环寿命。为了解决这个问题，本文已经通过调节戊二醛（GA）辅助的阳离子二肽（CDP）组装体来开发了一种具有良好调节的大小和结构的可注射的基于二肽的纳米载体。加载模型光敏药物（Ce6）并用肝素聚合物（Hep）进一步修饰CDP纳米颗粒（NPs）后，可以得到所需的基于二肽的NP，平均直径为100 rim，表面电荷为-25 mV，这是有利的具有增强的渗透性和保留效果。值得注意的是，具有Ce6负载的基于二肽的NPs相对于游离Ce6溶液具有更长的抗调理循环寿命，随后，它们在体内获得了最佳的抗癌效果。它们不会引起体重减轻或在器官中引起不良的免疫活化，这意味着所设计的载体具有良好的生物安全性。综上所述，通过GA辅助组装的基于二肽的递送载体可能为开发可精确控制的纳米结构以实现有效的抗肿瘤治疗提供新的选择。

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