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首页> 外文期刊>ACS applied materials & interfaces >Microfluidic Synthesis and Biological Evaluation of Photothermal Biodegradable Copper Sulfide Nanoparticles
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Microfluidic Synthesis and Biological Evaluation of Photothermal Biodegradable Copper Sulfide Nanoparticles

机译：光热可生物降解硫化铜纳米粒子的微流合成与生物评价。

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摘要

The continuous synthesis of biodegradable photo thermal copper sulfide nanoparticles has been carried out with the aid of a microfluidic platform. A comparative physicochemical characterization of the resulting products from the microreactor and from a conventional batch reactor has been performed. The microreactor is able to operate in a continuous manner and with a 4-fold reduction in the synthesis times compared to that of the conventional batch reactor producing nanoparticles with the same physicochemical requirements. Biodegradation subproducts obtained under simulated physiological conditions have been identified, and a complete cytotoxicological analysis on different cell lines was performed. The photothermal effect of those nanomaterials has been demonstrated in vitro as well as their ability to generate reactive oxygen species.
机译：借助于微流体平台已经进行了可生物降解的光热硫化铜纳米颗粒的连续合成。对来自微反应器和常规间歇反应器的所得产物进行了比较物理化学表征。与生产具有相同物理化学要求的纳米颗粒的常规间歇式反应器相比，微反应器能够以连续方式操作，并且合成时间减少了4倍。已经鉴定了在模拟生理条件下获得的生物降解副产物，并对不同细胞系进行了完整的细胞毒理学分析。这些纳米材料的光热效应及其在体外产生活性氧的能力已得到证明。

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