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首页> 外文期刊>ACS applied materials & interfaces >Dopamine Modified Organic-Inorganic Hybrid Coating for Antimicrobial and Osteogenesis
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Dopamine Modified Organic-Inorganic Hybrid Coating for Antimicrobial and Osteogenesis

机译：多巴胺修饰的有机-无机杂化涂层，用于抗菌和成骨

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摘要

A hybrid coating composed of hydroxyapatite (HA), Ag nanoparticles (NPs), and chitosan (CS) was successfully prepared on a Ti substrate by a layer-by-layer assembly process. A polydopamine-assisted (PDA-assisted) coating showed a good bond with HA. Ag NPs were uniformly distributed into the hybrid coating through a solution method and ultraviolet light reduction. A CS nanofilm was deposited via spin coating to control the release of Ag+ from the hybrid coating. The results disclosed that the 3-layer CS coating could efficiently control the release of Ag+ from the hybrid coating via the Fickian diffusion mechanism and that the PDA/HA/Ag/CS-1 coating exhibited antibacterial ratios of 63.0% and 51.8% against E. coli and S. aureus, respectively. Furthermore, the normal structure of E. coli was obviously destroyed by two types of Ag doped coatings. The cell viability assay showed that CS effectively reduced the cytotoxicity of the hybrid coating after a 7 day incubation. The hybrid coating presented high ALP activities at days 3 and 14. The results reveal that hybrid coatings can endow Ti implants with good antibacterial capability as well as cell viability and osteogenic activity.
机译：通过逐层组装工艺成功地在Ti基体上制备了由羟基磷灰石（HA），银纳米颗粒（NPs）和壳聚糖（CS）组成的杂化涂层。聚多巴胺辅助（PDA辅助）涂层与HA表现出良好的粘合性。通过溶液法和紫外光还原法将Ag NP均匀地分布在混合涂层中。通过旋涂沉积CS纳米膜以控制Ag +从杂化涂层的释放。结果表明，三层CS涂层可以通过Fickian扩散机制有效地控制Ag +从杂化涂层中的释放，并且PDA / HA / Ag / CS-1涂层对E的抗菌率分别为63.0％和51.8％。分别为大肠杆菌和金黄色葡萄球菌。此外，两种类型的掺银涂层明显破坏了大肠杆菌的正常结构。细胞活力分析表明，在孵育7天后，CS有效降低了杂化涂层的细胞毒性。杂化涂层在第3天和第14天表现出较高的ALP活性。结果表明，杂化涂层可以赋予Ti植入物良好的抗菌能力以及细胞活力和成骨活性。

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