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首页> 外文期刊>American Journal of Physiology >Effect of interleukin-18 on mouse core body temperature.
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Effect of interleukin-18 on mouse core body temperature.

机译：IL-18对小鼠核心体温的影响。

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摘要

We have studied, using a telemetry system, the pyrogenic properties of recombinant murine interleukin-18 (rmIL-18) injected into the peritoneum of C57BL/6 mice. The effect of IL-18 was compared with the febrile response induced by human IL-1beta, lipopolysaccharide (LPS), and recombinant murine interferon-gamma (rmIFN-gamma). Both IL-1beta and LPS induced a febrile response within the first hour after the intraperitoneal injection, whereas rmIL-18 (10-200 microg/kg) and rmIFN-gamma (10-150 microg/kg) did not cause significant changes in the core body temperature of mice. Surprisingly, increasing doses of IL-18, injected intraperitoneally 30 min before IL-1beta, significantly reduced the IL-1beta-induced fever response. In contrast, the same pretreatment with IL-18 did not modify the febrile response induced by LPS. IFN-gamma does not seem to play a role in the IL-18-mediated attenuation of IL-1beta-induced fever. In fact, there was no elevation of IFN-gamma in the serum of mice treated with IL-18, and a pretreatment with IFN-gamma did not modify the fever response induced by IL-1beta. We conclude that IL-18 is not pyrogenic when injected intraperitoneally in C57BL/6 mice. Furthermore, a pretreatment with IL-18, 30 min before IL-1beta, attenuates the febrile response induced by IL-1beta.
机译：我们已经使用遥测系统研究了注入C57BL / 6小鼠腹膜的重组鼠白细胞介素18（rmIL-18）的热原性。将IL-18的作用与人IL-1β，脂多糖（LPS）和重组鼠干扰素-γ（rmIFN-γ）诱导的发热反应进行了比较。 IL-1beta和LPS均在腹膜内注射后的第一小时内引起发热反应，而rmIL-18（10-200 microg / kg）和rmIFN-γ（10-150 microg / kg）并未引起显着变化。小鼠的核心体温。出人意料的是，在IL-1beta之前30分钟腹膜内注射的IL-18剂量增加，显着降低了IL-1beta引起的发热反应。相反，用IL-18进行的相同预处理并未改变LPS诱导的发热反应。 IFN-γ似乎在IL-18介导的IL-1β诱导的发热减弱中不起作用。实际上，用IL-18治疗的小鼠血清中IFN-γ不会升高，并且IFN-γ的预处理不会改变IL-1β诱导的发热反应。我们得出的结论是，在C57BL / 6小鼠腹膜内注射IL-18不会致热。此外，在IL-1beta之前30分钟用IL-18进行预处理可减弱由IL-1beta诱导的发热反应。

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