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首页> 外文期刊>American Journal of Physiology >Lung retinol storing cells synthesize and secrete retinoic acid, an inducer of alveolus formation.
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Lung retinol storing cells synthesize and secrete retinoic acid, an inducer of alveolus formation.

机译：肺视黄醇储存细胞合成并分泌视黄酸，这是肺泡形成的诱导剂。

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摘要

Retinoids play a key role in the formation of pulmonary alveoli. Lipid interstitial cells (LICs) of the alveolar wall store retinol and are concentrated at sites of alveolus formation, suggesting they are an endogenous source of retinoids for alveolus formation. We show in cultured rat lung cells that LICs synthesize and secrete all-trans retinoic acid (ATRA); its secretion is halved by dexamethasone, an inhibitor of alveolus formation. In a second alveolar wall cell, the pulmonary microvascular endothelial cell (PMVC), ATRA increases expression of the mRNA of cellular retinol binding protein-I (CRBP-I), a protein involved in ATRA synthesis. Serum-free, exogenous ATRA-free medium conditioned by LICs rich in retinol storage granules caused a 10-fold greater increase of CRBP-I mRNA in PMVCs than media conditioned by LICs with few retinol storage granules. This action of medium conditioned by retinol storage granule-rich LICs is decreased by a retinoic acid receptor pan-antagonist and by a retinoid X receptor pan-antagonist, suggesting the responsible molecule(s) is a retinoid and that retinoid signaling occurs in a paracrine fashion.
机译：类维生素A在肺泡的形成中起关键作用。肺泡壁的脂质间质细胞（LIC）存储视黄醇，并集中在肺泡形成的部位，表明它们是肺泡形成的类维生素A的内源性来源。我们在培养的大鼠肺细胞中显示LIC合成并分泌全反式维甲酸（ATRA）;地塞米松是肺泡形成的抑制剂，其分泌减少了一半。在第二个肺泡壁细胞，即肺微血管内皮细胞（PMVC）中，ATRA增加了细胞视黄醇结合蛋白I（CRBP-1）的mRNA表达，该蛋白参与了ATRA的合成。由富含视黄醇储存颗粒的LICs调节的无血清，无外源性ATRA的培养基导致PMVCs中CRBP-1 mRNA的增加比由视黄醇储存颗粒少的LICs调节的培养基大10倍。视黄酸受体泛拮抗剂和类维生素X受体泛拮抗剂降低了视黄醇储存颗粒富含LICs调节的培养基的这种作用，表明负责的分子是类视黄醇，并且类视黄醇信号传导在旁分泌细胞中时尚。

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