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首页> 外文期刊>American Journal of Physiology >Cardiac-specific norepinephrine mass transport and its relationship to left ventricular size and systolic performance.
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Cardiac-specific norepinephrine mass transport and its relationship to left ventricular size and systolic performance.

机译：特定于心脏的去甲肾上腺素的大众运输及其与左心室大小和收缩性能的关系。

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Objectives of this study were to develop a technique for quantifying cardiac-specific norepinephrine (NE) mass transport and determine whether cardiac NE kinetic modeling parameters were related to physiological variables of left ventricular (LV) size and systolic performance in nine patients with chronic mitral regurgitation. Biplane contrast cineventriculograms were used to determine LV size and ejection fraction (EF), micromanometer LV pressures and radionuclide LV volumes from a range of loading conditions to calculate LV end-systolic elastance, and [(3)H]NE infusions with LV and coronary sinus sampling for [(3)H]NE and endogenous NE during and after termination of infusions to model NE mass transport. Total NE release rate into cardiac interstitial fluid (M(IF)(R)) averaged 859 +/- 214 and NE released de novo into cardiac interstitial fluid (M(IF)(u,r,en)) averaged 546 +/- 174 pmol/min. Both M(IF)(R) and M(IF)(u,r,en)correlated directly with LV end-systolic volume (r = 0.84, P 0.005; r r = -0.81, P = 0.008); and inversely with LV end-systolic elastance values, optimally fit by a nonlinear function (r = 0.89, P = 0.04; r = 0.96, P = 0.01). We conclude that total and newly released NE into interstitial fluid of the heart, determined by regional mass transport kinetic model, are specific measures of regional cardiac-specific sympathetic nervous system activity and are strongly related to measures of LV size and systolic performance. These data support the concept that this new model of organ-specific NE kinetics has physiological relevance.
机译：这项研究的目的是开发一种量化心脏特异性去甲肾上腺素（NE）转运的技术，并确定9名慢性二尖瓣反流患者的心脏NE动力学建模参数是否与左心室（LV）大小的生理变量和收缩性能有关。使用双平面对比电影图来确定一系列负荷条件下的LV大小和射血分数（EF），显微压力计LV压力和放射性核素LV体积，以计算LV收缩末期弹性，以及[（3）H] NE输注LV和冠状动脉[（3）H] NE和内源性NE输注期间和结束输注以模拟NE大量运输时进行窦采样。 NE向心脏组织液（M（IF）（R））的总释放速率平均为859 +/- 214，NE从头开始向心脏组织液（M（IF）（u，r，en））释放的NE平均为546 +/- 174 pmol /分钟。 M（IF）（R）和M（IF）（u，r，en）与左室收缩末期容积直接相关（r = 0.84，P 0.005; r r = -0.81，P = 0.008）;与左室收缩末期弹性值相反，通过非线性函数最佳拟合（r = 0.89，P = 0.04; r = 0.96，P = 0.01）。我们得出的结论是，由区域传质动力学模型确定的总的和新释放的NE进入心脏的组织液是区域性心脏特异性交感神经系统活动的特定度量，并且与LV大小和收缩期性能密切相关。这些数据支持这一概念，即这种新的器官特异性NE动力学模型具有生理相关性。

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