• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Direct regulation of lipolysis by interleukin-15 in primary pig adipocytes.
【24h】

Direct regulation of lipolysis by interleukin-15 in primary pig adipocytes.

机译：白介素15在原代猪脂肪细胞中直接调节脂解作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We recently provided evidence that interleukin-15 (IL-15) is expressed lowly in the pig adipocyte and that interferon-gamma (IFN-gamma) markedly increases this expression through a pathway regulated in part by protein kinase C. In the present study, we tested the hypothesis that IL-15 acts directly on the adipocyte to regulate lipid accretion by enhancing lipolysis or suppressing lipogenesis. Using recombinant porcine IL-15, we determined that this cytokine stimulates lipolysis in a dose-dependent manner (P < 0.001). Furthermore, comparative studies with other cytokines showed that IL-15 is more potent in its acute stimulation of lipolysis than either TNF-alpha, IL-6, or LPS (P < 0.001). When specific inhibitors of protein kinase A or Janus kinase are present, the lipolytic effect of IL-15 is attenuated (P < 0.01). These data indicate that, in addition to its regulation of muscle protein accretion and T-cell growth and development, IL-15 also targets the adipocyte directly to alter stimulate lipolysis.Thus, when induced by IFN-gamma or other inflammatory mediators, IL-15 may be a significant homeorhetic factor that mobilizes and directs energy away from the adipocyte to other cells during the acute phase of the inflammatory response.
机译：我们最近提供的证据表明，猪脂肪细胞中白介素15（IL-15）的表达很低，而干扰素-γ（IFN-γ）则通过部分受蛋白激酶C调节的途径显着增加了这种表达。在本研究中，我们测试了IL-15通过增强脂解作用或抑制脂肪生成直接作用于脂肪细胞以调节脂质积聚的假说。使用重组猪IL-15，我们确定该细胞因子以剂量依赖性方式刺激脂解（P <0.001）。此外，与其他细胞因子的比较研究表明，IL-15在其急性脂解刺激方面比TNF-α，IL-6或LPS更为有效（P <0.001）。当存在蛋白激酶A或Janus激酶的特异性抑制剂时，IL-15的脂解作用减弱（P <0.01）。这些数据表明，IL-15除了调节肌肉蛋白的增生和T细胞的生长和发育外，还直接靶向脂肪细胞以改变刺激性脂解作用。因此，当被IFN-γ或其他炎症介质介导时，IL- 15图15可能是重要的同种异体因子，其在炎症反应的急性期期间将脂肪细胞的能量动员并将其引导至其他细胞。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号