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首页> 外文期刊>American Journal of Physiology >Cardiac structural and functional responses to salt loading in SHR.
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Cardiac structural and functional responses to salt loading in SHR.

机译：SHR对盐负荷的心脏结构和功能反应。

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Increased dietary salt intake induces cardiac fibrosis in the spontaneously hypertensive rat (SHR), yet little information details its effects on left ventricular (LV) function. Additionally, young normotensive rats are more sensitive to the trophic effect of dietary sodium than older rats. Thus cardiac responses to salt loading were evaluated at two ages in the SHR; LV collagen content was also examined. SHR (8 or 20 wk of age) were given an 8% salt diet; their age-matched controls received standard chow. Echocardiographic indexes, arterial pressure, and LV hydroxyproline concentration were measured at 16 and 52 wk in the younger and older SHR groups, respectively. In most SHR, salt excess increased arterial pressure, LV mass, and hydroxyproline concentration and impaired LV relaxation manifested by prolonged isovolumic relaxation time, decreased early and atrial filling velocity ratio (V(E)/V(A)), and slower propagation velocity of E wave (V(P)). LV systolic function remained normal. However, one-quarter of the young salt-loaded SHR developed cardiac failure with systolic and diastolic dysfunction associated with greater LV mass and ventricular fibrosis. They also had lower arterial pressure, decreased fractional shortening, and a restrictive pattern of mitral flow. Moreover, the shorter deceleration time of the E wave and increased V(E)/V(P), an index of LV filling pressure, indicated increased LV stiffness in these rats. These findings demonstrated that sodium sensitivity in SHR is manifested not only by further pressure elevation but also by significant LV functional impairment that most likely is related to enhanced ventricular fibrosis. Moreover, the SHR are more susceptible to cardiac damage when high dietary salt is introduced earlier in life.
机译：饮食中盐摄入量的增加会诱发自发性高血压大鼠（SHR）的心脏纤维化，但很少有信息详细说明其对左心室（LV）功能的影响。此外，年轻的血压正常的大鼠对膳食钠的营养作用比老年的大鼠更敏感。因此，在两个年龄段的SHR中评估了对盐分负荷的心脏反应。还检查了LV胶原蛋白含量。 SHR（8周或20周龄）的饮食含盐量为8％;他们的年龄相匹配的对照组接受标准食物。在年轻和老年SHR组中，超声心动图指数，动脉压和LV羟脯氨酸浓度分别在16和52 wk时测量。在大多数SHR中，盐过量会增加动脉压，LV质量和羟脯氨酸浓度，并削弱LV舒张，其表现为等容舒张时间延长，早期和心房充盈速度比（V（E）/ V（A））降低，以及传播速度较慢E波（V（P））。左室收缩功能保持正常。然而，四分之一的年轻盐负荷性SHR发生心力衰竭，伴有收缩和舒张功能障碍，并伴有更大的LV量和心室纤维化。他们还具有较低的动脉压，缩短的分数缩短和二尖瓣血流的限制性模式。此外，E波的减速时间更短，V（E）/ V（P）（LV充盈压力的指标）增加，表明这些大鼠的LV刚度增加。这些发现表明，SHR中的钠敏感性不仅表现为进一步的压力升高，还表现为明显的LV功能障碍，这很可能与心室纤维化增强有关。此外，当在生活中较早引入高饮食盐时，SHR更容易受到心脏损害。

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