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首页> 外文期刊>American Journal of Physiology >Regional gastric contractility alterations in a diabetic gastroparesis mouse model: effects of cholinergic and serotoninergic stimulation.
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Regional gastric contractility alterations in a diabetic gastroparesis mouse model: effects of cholinergic and serotoninergic stimulation.

机译：糖尿病性胃轻瘫小鼠模型中的区域胃收缩力改变：胆碱能和5-羟色胺能刺激的影响。

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The C57BLKS/J db/db mouse develops hyperglycemia and has delayed gastric emptying that is improved with tegaserod, a partial 5-HT4 agonist. Our aims here were to determine regional gastric contractility alterations in C57BLKS/J db/db mice and to determine the effects of serotonin and tegaserod. The contractile effects of bethanechol, serotonin, and tegaserod in fundic, antral, and pyloric circular muscle were compared in C57BLKS/J db/db mice and normal littermates. The effects of tetrodotoxin, atropine, and 5-HT receptor antagonists were studied. Contractions in response to bethanechol were decreased in the fundus, similar in the antrum, but increased in the pylorus in diabetic mice compared with controls. Serotonin and, to a lesser extent, tegaserod caused contractions that were more pronounced in the fundus than in the antrum and pylorus in both diabetic and normal mice. Serotonin-induced contractions were partially inhibited by atropine, the 5-HT4 antagonist GR113808, and the 5-HT2 antagonist cinanseron but not tetrodotoxin. Regional gastric contractility alterations are present in this diabetic gastroparesis mouse model. Fundic contractility was decreased, but pyloric contractility was increased in the pylorus to cholinergic stimulation in diabetic mice. Serotonin's contractile effect is mediated, in part, through muscarinic, 5-HT2, and 5-HT4 receptors. This study suggests that fundic hypomotility and pyloric hypercontractility, rather than antral hypomotility, play important roles for the gastric dysmotility that occurs in diabetes.
机译：C57BLKS / J db / db小鼠发展为高血糖症，并延迟了胃排空，这可通过部分5-HT4激动剂替加色罗改善。我们的目标是确定C57BLKS / J db / db小鼠的局部胃收缩力改变，并确定5-羟色胺和替加色罗的作用。比较了C57BLKS / J db / db小鼠和正常同窝仔小鼠中苯甲酚，5-羟色胺和替加色罗在眼底，肛门和幽门环形肌中的收缩作用。研究了河豚毒素，阿托品和5-HT受体拮抗剂的作用。与对照组相比，糖尿病小鼠对苯甲酰胆碱的反应收缩减少，胃窦相似，但幽门的收缩增加。在糖尿病小鼠和正常小鼠中，血清素和（在较小程度上）替加色罗引起的收缩比在胃窦和幽门的收缩更明显。 5-羟色胺诱导的收缩被阿托品，5-HT4拮抗剂GR113808和5-HT2拮抗剂cinanseron部分抑制，但河豚毒素则没有。在这种糖尿病性胃轻瘫小鼠模型中存在区域性胃收缩力改变。在糖尿病小鼠中，幽门对胆碱能刺激的胃底收缩力降低，但是幽门收缩力增加。 5-羟色胺的收缩作用部分通过毒蕈碱，5-HT2和5-HT4受体介导。这项研究表明，胃底动力不足和幽门过度收缩，而不是胃窦动力不足，对糖尿病中发生的胃动力异常起重要作用。

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