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首页> 外文期刊>American Journal of Physiology >Left atrial conduit volume is generated by deviation from the constant-volume state of the left heart: a combined MRI-echocardiographic study.
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Left atrial conduit volume is generated by deviation from the constant-volume state of the left heart: a combined MRI-echocardiographic study.

机译：左心房容积是通过偏离左心脏的恒定容积状态而产生的：MRI-超声心动图联合研究。

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摘要

Although modeling the four-chambered heart as a constant-volume pump successfully predicts causal physiological relationships between cardiac indexes previously deemed unrelated, the real four-chambered heart slightly deviates from the constant-volume state by ventricular end systole. This deviation has consequences that affect chamber function, specifically, left atrial (LA) function. LA attributes have been characterized as booster pump, reservoir, and conduit functions, yet characterization of their temporal occurrence or their causal relationship to global heart function has been lacking. We investigated LA function in the context of the constant-volume attribute of the left heart in 10 normal subjects using cardiac magnetic resonance imaging (MRI) and contemporaneous Doppler echocardiography synchronized via ECG. Left ventricular (LV) and LA volumes as a function of time were determined via MRI. Transmitral flow, pulmonary vein (PV) flow, and lateral mitral annular velocity were recorded via echocardiography. The relationship between the MRI-determined diastolic LA conduit-volume (LACV) filling rate and systolic LA filling rate correlate well with the relationship between the echocardiographically determined average flow rate during the early portion of the PV D wave and the average flow rate during the PV S wave (r 0.76). We conclude that the end-systolic deviation from constant volume for the left heart requires the generation of the LACV during diastole. Because early rapid filling of the left ventricle is the driving force for LACV generation while the left atrium remains passive, it may be more appropriate to consider LACV to be a property of ventricular diastolic rather than atrial function.
机译：尽管将四腔心脏建模为恒定容积泵可以成功预测先前认为不相关的心脏指数之间的因果生理关系，但实际的四腔心脏由于心室收缩期而略微偏离恒定容积状态。这种偏差会影响房室功能，特别是左心房（LA）功能。洛杉矶的属性已被表征为增压泵，储液器和导管功能，但缺乏对它们的短暂发生或它们与整体心脏功能的因果关系的表征。我们使用心电图同步检查的心脏磁共振成像（MRI）和同期多普勒超声心动图技术，在10名正常受试者的左心恒定体积属性的背景下研究了LA功能。通过MRI确定左心室（LV）和LA体积作为时间的函数。通过超声心动图记录传输流量，肺静脉（PV）流量和二尖瓣外侧环速度。 MRI确定的舒张期LA导管容积（LACV）和收缩期LA灌注率之间的关系与超声心动图确定的PV D波早期的平均流速与超声心动图期间的平均流速之间的关系密切相关。 PV S波（r 0.76）。我们得出的结论是，左心恒定容积的收缩末期偏差需要在舒张期产生LACV。由于左心室的早期快速充盈是产生LACV的驱动力，而左心房仍然是被动的，因此将LACV视为心室舒张性而不是心房功能更合适。

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