• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Characterization of the cerebral cortical representation of heartburn in GERD patients.
【24h】

Characterization of the cerebral cortical representation of heartburn in GERD patients.

机译：GERD患者胃灼热的大脑皮层表征的特征。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although symptoms arising from the esophagus such as heartburn and pain can at times become challenging clinical problems, esophageal viscerosensation, especially with regard to chemical stimulation in humans, is incompletely understood. Our aims were 1) to characterize and ascertain the reproducibility of cerebral cortical registration of heartburn and 2) to elucidate the differences between these findings and those of esophageal subliminal acid stimulation in asymptomatic controls. We studied 11 gastroesophageal reflux disease (GERD) patients (9 males, 30-55 yr) and 15 healthy controls (8 males, 21-49 yr). Cerebral cortical functional magnetic resonance imaging (fMRI) activity was recorded twice in each subject, during two 5-min intervals of 0.1 N HCl, separated by 5 min of NaCl perfusion. Time from onset of acid perfusion to instant of fMRI signal increase and first report of heartburn averaged 1.60 +/- 0.80 and 1.85 +/- 0.60 min, respectively. Average maximum percent signal increase in the GERD patients (16.3 +/- 3.5%) was significantly greater than that of healthy controls (3.8 +/- 0.9%; P < 0.01). Temporal fMRI signal characteristics during heartburn were significantly different from those of subliminal acid stimulation in controls (P < 0.01). Activated cortical regions included sensory/motor, parieto-occipital, cingulate and prefrontal regions, and the insula. There was 92% concordance between the activated Brodmann areas in repeated studies of GERD patients. Cortical activity associated with perceived and unperceived esophageal acid exposure in GERD patients and healthy controls, respectively, involves multiple brain regions but occurs more rapidly and with greater intensity in GERD patients than the activity in response to subliminal acid exposure in healthy controls. The cortical pain-processing pathway seems to be involved in perception of esophageal acid exposure and could explain the variations encountered in clinical practice defining this sensation.
机译：尽管由食道引起的症状（如烧心和疼痛）有时可能成为具有挑战性的临床问题，但对食管内脏感觉，尤其是对人的化学刺激，尚不完全了解。我们的目标是1）表征和确定烧心的大脑皮层配准的可重复性，以及2）阐明这些发现与无症状对照中食管下潜酸刺激的发现之间的差异。我们研究了11例胃食管反流病（GERD）患者（9例男性，年龄30-55岁）和15例健康对照（8例男性，年龄21-49岁）。每个受试者两次记录大脑皮层功能磁共振成像（fMRI）活动，两次间隔为5分钟的0.1 N HCl，每次间隔5分钟的NaCl灌注。从酸灌注开始到功能性磁共振成像信号增加的时间以及首次烧心报告的时间分别平均为1.60 +/- 0.80和1.85 +/- 0.60分钟。 GERD患者的平均最大信号增加百分比（16.3 +/- 3.5％）显着大于健康对照组（3.8 +/- 0.9％; P <0.01）。胃灼热过程中的时间功能性MRI信号特征与对照组的阈值以下潜伏期酸刺激显着不同（P <0.01）。激活的皮质区域包括感觉/运动，顶枕，扣带和前额叶区域以及岛状。在GERD患者的重复研究中，激活的Brodmann区之间的一致性为92％。在GERD患者和健康对照组中，分别与感知和未感知的食管酸暴露相关的皮层活动涉及多个大脑区域，但在GERD患者中，其皮层活动的发生速度比健康对照组中对阈值以下的活动更迅速且强度更大。皮质疼痛处理途径似乎与食道酸暴露的感觉有关，并且可以解释定义这种感觉的临床实践中遇到的变化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号