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首页> 外文期刊>American Journal of Physiology >Gender affects calf venous compliance at rest and during baroreceptor unloading in humans.
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Gender affects calf venous compliance at rest and during baroreceptor unloading in humans.

机译：性别会影响人在休息和压力感受器卸载过程中小腿静脉的顺应性。

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摘要

Leg venous compliance is a determinant of peripheral venous pooling during orthostatic stress such that high venous compliance could contribute to reduced orthostatic tolerance. We tested the hypotheses that 1) calf venous compliance is reduced during baroreceptor unloading, and 2) calf venous compliance is greater in women than men. Twelve men (27 +/- 2 yr) and 12 women (25 +/- 2 yr) were studied in the supine posture. Calf venous compliance was determined by inflating a thigh venous collecting cuff to 60 mmHg for 8 min and then decreasing cuff pressure at a rate of 1 mmHg/s to 0 mmHg. The slope of the pressure-compliance relation (compliance = beta(1) + 2.beta(2).cuff pressure), which is the first derivative of the quadratic pressure-volume relation [(Deltalimb volume) = beta(0) + beta(1).(cuff pressure) + beta(2).(cuff pressure)(2)] during the reduction in collecting cuff pressure, was used to assess venous compliance at baseline and during one-legged lower body negative pressure (LBNP; -50 mmHg). At baseline, calf venous compliance was 48% lower (P < 0.001) in women than men and decreased in men (Delta-25 +/- 8%; P < 0.05) but not women (Delta1 +/- 11%) during LBNP. Rhythmic ischemic handgrip (Delta6 +/- 9%) and cold pressor testing (Delta-9 +/- 7%) did not alter calf venous compliance in a subgroup of men (n = 6). These data indicate gender-dependent effects on calf venous compliance under conditions associated with low sympathetic outflow (i.e., rest) and high sympathetic outflow (i.e., LBNP). However, they cannot explain gender-associated differences in orthostatic tolerance.
机译：腿部静脉顺应性是体位性应激期间周围静脉合并的决定因素，因此高静脉顺应性可能导致体位性耐受性降低。我们检验了以下假设：1）在压力感受器卸载过程中小腿静脉顺应性降低; 2）女性的小腿静脉顺应性大于男性。以仰卧姿势研究了十二名男性（27 +/- 2岁）和十二名女性（25 +/- 2岁）。通过将大腿静脉收集套囊充气至60 mmHg 8分钟，然后以1 mmHg / s的速率将套囊压力降低至0 mmHg，确定小腿静脉的顺应性。压力-服从关系的斜率（服从= beta（1）+ 2.beta（2）。袖带压力），它是二次压力-体积关系的一阶导数[（ΔΔlimb体积）= beta（0）+ beta（1）。（袖带压力）+ beta（2）。（袖带压力）（2）]在收集袖带压降低的过程中，用于评估基线和单腿下肢负压（LBNP）时的静脉顺应性; -50 mmHg）。在基线时，LBNP期间女性的小腿静脉顺应性比男性低48％（P <0.001），男性降低（Delta-25 +/- 8％; P <0.05），但女性没有降低（Delta1 +/- 11％） 。节律性缺血性手握（Delta6 +/- 9％）和冷加压测试（Delta-9 +/- 7％）在男性亚组（n = 6）中未改变小腿静脉顺应性。这些数据表明在与低交感性流出（即休息）和高交感性流出（即LBNP）有关的条件下，对小腿静脉顺应性的性别依赖性影响。但是，他们不能解释与性别相关的体位耐受性差异。

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