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首页> 外文期刊>American Journal of Physiology >Dynamics of virtual electrode-induced scroll-wave reentry in a 3D bidomain model.
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Dynamics of virtual electrode-induced scroll-wave reentry in a 3D bidomain model.

机译：在3D双域模型中虚拟电极引起的涡旋波折返的动力学。

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Functional reentry in the heart can be caused by a wave front of excitation rotating around its edge. Previous simulations on the basis of monodomain cable equations predicted the existence of self-sustained, vortex-like wave fronts (scroll waves) rotating around a filament in three dimensions. In our simulations, we used the more accurate bidomain model with modified Beeler-Reuter ionic kinetics to study the dynamics of scroll-wave filaments in a 16 x 8 x 1.5-mm slab of ventricular tissue with straight fibers. Wave fronts were identified as the areas with inward current. Their edges represented the filaments. Both transmural and intramural reentries with I- and U-shaped filaments, respectively, were obtained by the S1-S2 point stimulation protocol through the virtual electrode-induced phase singularity mechanism. The filaments meandered along elongated trajectories and tended to attach to the tissue boundaries exposed to air (no current flow) rather than to the bath (zero extracellular potential). They completely detached from electroporated (zero transmembrane potential) boundaries. In our simulations, the presence of the bath led to generation of only U-shaped filaments, which survived for the 1.5-mm-thick slab but not for the slabs of 0.5- or 3-mm thicknesses. Thus boundary conditions may be another determinant of the type and dynamics of reentry.
机译：心脏的功能性折返可能是由绕其边缘旋转的激发波阵面引起的。先前基于单畴电缆方程式的模拟预测了存在自维持的，像涡流一样的波前（涡旋波）在三个维度上围绕细丝旋转的情况。在我们的模拟中，我们使用具有更精确的Beeler-Reuter离子动力学的更精确的双畴模型来研究在16 x 8 x 1.5 mm直纤维心室组织平板中涡旋波丝的动力学。波前被确定为具有内向电流的区域。它们的边缘代表细丝。通过S1-S2点刺激方案，通过虚拟电极诱导的相位奇异机制，分别获得了带有I型和U型细丝的透壁折返和壁内折返。细丝沿着细长的轨迹蜿蜒，倾向于附着在暴露于空气（无电流）的组织边界上，而不是附着在浴液（零细胞外电位）上。它们与电穿孔（跨膜电位为零）边界完全脱离。在我们的模拟中，熔池的存在导致仅生成U形长丝，这种长丝在厚度为1.5毫米的板坯中幸存下来，而在厚度为0.5毫米或3毫米的板坯中则没有。因此，边界条件可能是折返类型和动力学的另一个决定因素。

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