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首页> 外文期刊>American Journal of Physiology >Expression of NPY Y1 and Y5 receptors in the hypothalamic paraventricular nucleus of aged Fischer 344 rats.
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Expression of NPY Y1 and Y5 receptors in the hypothalamic paraventricular nucleus of aged Fischer 344 rats.

机译：老年Fischer 344大鼠下丘脑室旁核中NPY Y1和Y5受体的表达。

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摘要

Many mammals, nearing the end of life, spontaneously decrease their food intake and body weight, a stage we refer to as senescence. The spontaneous decrease in food intake and body weight is associated with attenuated responses to intracerebroventricular injections of neuropeptide Y (NPY) compared with old presenescent or with young adult rats. In the present study, we tested the hypothesis that this blunted responsiveness involves the number and expression of hypothalamic paraventricular nucleus (PVN) Y(1) and/or Y(5) NPY receptors, both of which are thought to mediate NPY-induced food intake. We found no significant difference in mRNA levels, via quantitative PCR, for Y(1) and Y(5) receptors in the PVN of senescent vs. presenescent rats. In contrast, immunohistochemistry indicated that the number of PVN neurons staining for Y(1) receptor protein was greater in presenescent compared with senescent rats. We conclude that a decreased expression and number of Y(1) or Y(5) receptors in the PVN cannot explain the attenuated responsiveness of the senescent rats to exogenous NPY.
机译：许多哺乳动物，在生命快要尽头时，会自发地减少食物摄入量和体重，这一阶段我们称为衰老。与老年衰老或成年大鼠相比，食物摄入量和体重的自发减少与对脑室内注射神经肽Y（NPY）的反应减弱有关。在本研究中，我们测试了以下假设：这种钝性反应涉及下丘脑室旁核（PVN）Y（1）和/或Y（5）NPY受体的数量和表达，两者均被认为可介导NPY诱导的食物录取。通过定量PCR，我们发现衰老与衰老前大鼠的PVN中的Y（1）和Y（5）受体在mRNA水平上没有显着差异。相比之下，免疫组织化学表明，与衰老大鼠相比，衰老前的PVN神经元染色的Y（1）受体蛋白数量更多。我们得出结论，PVN中Y（1）或Y（5）受体的表达和数量减少不能解释衰老大鼠对外源性NPY的减弱的反应性。

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