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首页> 外文期刊>American Journal of Physiology >Acipimox enhances spontaneous growth hormone secretion in obese women.
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Acipimox enhances spontaneous growth hormone secretion in obese women.

机译：Acipimox可增强肥胖女性的自发生长激素分泌。

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We hypothesized that a high circulating free fatty acid (FFA) concentration is involved in the pathogenesis of hyposomatotropism associated with obesity. To evaluate this hypothesis, 10 healthy premenopausal women (body mass index 33.8 +/- 1.0 kg/m(2)) were studied in the follicular phase of their menstrual cycle at two occasions with a time interval of at least 8 wk, where body weight remained stable. Subjects were randomly assigned to treatment with either acipimox (an inhibitor of lipolysis, 250 mg orally 4 times daily) or placebo in a double-blind crossover design, starting 1 day before admission until the end of the blood sampling period. Blood samples were taken during 24 h with a sampling interval of 10 min for assessment of growth hormone (GH) concentrations, and GH secretion was estimated by deconvolution analysis. Identical methodology was used to study GH secretion in a historical control group of age-matched normal weight women. GH secretion was clearly blunted in obese women (total daily release 66 +/- 10 vs. lean controls: 201 +/- 23 mU x l(Vd)(-1) x 24 h(-1), P = 0.005, where l(Vd) is lite of distribution volume). Acipimox considerably enhanced total (113 +/- 50 vs. 66 +/- 10 mU x l(Vd)(-1) x 24 h(-1), P = 0.02) and pulsatile GH secretion (109 +/- 49 vs. 62 +/- 30 mU x l(Vd)(-1) x 24 h(-1), P = 0.02), but GH output remained lower compared with lean controls. Further analysis did not show any relationship between the effects of acipimox on GH secretion and regional body fat distribution. In conclusion, acipimox unleashes spontaneous GH secretion in obese women. It specifically enhances GH secretory burst mass. This might mean that lowering of systemic FFA concentrations by acipimox modulates neuroendocrine mechanisms that orchestrate the activity of the somatotropic ensemble.
机译：我们假设高循环游离脂肪酸（FFA）浓度与肥胖症有关的营养不良症的发病机理有关。为了评估这一假设，研究了10名健康的绝经前妇女（体重指数33.8 +/- 1.0 kg / m（2）），在两次月经周期至少为8周的卵泡期中，她们的身体体重保持稳定。从入院前1天开始直至血液采样期结束，以双盲交叉设计将受试者随机分配为接受acipimox（一种脂解抑制剂，每天250 mg，口服4次）或安慰剂治疗。在24小时内以10分钟的采样间隔采集血样以评估生长激素（GH）浓度，并通过解卷积分析评估GH分泌。使用相同的方法研究年龄匹配的正常体重妇女的历史对照组的GH分泌。肥胖妇女的GH分泌明显变钝（与瘦身对照组相比，每日总释放量为66 +/- 10，相对于瘦肉对照组为201 +/- 23 mU xl（Vd）（-1）x 24 h（-1），P = 0.005，其中（Vd）是最小的分发量）。 Acipimox显着增强了总分泌量（113 +/- 50 vs. 66 +/- 10 mU xl（Vd）（-1）x 24 h（-1），P = 0.02）和搏动性GH分泌（109 +/- 49 vs. 62 +/- 30 mU xl（Vd）（-1）x 24 h（-1），P = 0.02），但是与瘦肉对照组相比，GH的产量仍然较低。进一步的分析未显示出阿西莫昔对GH分泌的影响与局部脂肪分布之间没有任何关系。总之，acipimox可释放肥胖女性的自发性GH分泌。它特别增加了GH分泌爆发量。这可能意味着通过acipimox降低全身FFA浓度可调节神经内分泌机制，从而协调着促生长系的活动。

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