首页> 外文期刊>American Journal of Physiology >Thymulin evokes IL-6-C/EBPbeta regenerative repair and TNF-alpha silencing during endotoxin exposure in fetal lung explants
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Thymulin evokes IL-6-C/EBPbeta regenerative repair and TNF-alpha silencing during endotoxin exposure in fetal lung explants

机译:Thymulin引起胎儿肺外植体内毒素暴露期间引起IL-6-C / EBPbeta再生修复和TNF-α沉默

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摘要

Chorioamnionitis is associated with increased risks of perinatal respiratory failure; however, components of the inflammatory acute-phase response are known to actively promote lung maturation. To manipulate this relationship, we examined the effect of the thymic immunomodulator thymulin on fetal lung mesenchyme-epithelial differentiation during exposure to Escherichia coli lipopolysaccharide (LPS). Gestation day 14 fetal rat lung explants were cultured for 96 h at fetal (23 mmHg) or ambient (142 mmHg) P0_2.
机译:绒毛膜羊膜炎会增加围产期呼吸衰竭的风险;然而,已知炎症性急性期反应的成分可积极促进肺成熟。为了操纵这种关系,我们检查了胸腺免疫调节剂胸腺肽对暴露于大肠杆菌脂多糖(LPS)期间胎儿肺间充质-上皮分化的影响。妊娠第14天,将胎儿大鼠肺外植体在胎儿(23 mmHg)或环境(142 mmHg)P0_2下培养96小时。

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