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首页> 外文期刊>American Journal of Physiology >Comparison of effects of exercise and diuretic on left ventricular geometry, mass, and insulin resistance in older hypertensive adults.
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Comparison of effects of exercise and diuretic on left ventricular geometry, mass, and insulin resistance in older hypertensive adults.

机译：比较运动和利尿剂对老年高血压成年人左心室几何形状，质量和胰岛素抵抗的影响。

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摘要

To compare the effects of exercise training and hydrochlorothiazide on left ventricular (LV) geometry and mass, blood pressure (BP), and hyperinsulinemia in older hypertensive adults, we studied 28 patients randomized either to a group (age 66.4 +/- 1.3 yr; n = 16) that exercised or to a group (age 65.3 +/- 1.2 yr; n = 12) that received hydrochlorothiazide for 6 mo. Endurance exercise training induced a 15% increase in peak aerobic power. The reduction in systolic BP was twofold greater with thiazide than with exercise (26.6 +/- 12.2 vs. 11.5 +/- 10.9 mmHg). Exercise and thiazide reduced LV wall thickness, LV mass index (14% in each group), and the LV wall thickness-to-radius ratio (h/r) similarly (exercise: before 0.48 +/- 0.2, after 0.42 +/- 0.01; thiazide: before 0.47 +/- 0.04, after 0.40 +/- 0.04; P = 0.017). The reductions in systolic BP and h/r were correlated in the exercise group (r = 0.70, P = 0.005) but not in the thiazide group. Exercise training reduced glucose-stimulated hyperinsulinemia (before: 13.65 +/- 2.6 vs. 9.84 +/- 1.5 mU.ml(-1).min; P 0.04) and insulin resistance. Thiazide did not affect plasma insulin levels. The results suggest that although exercise is less effective in reducing systolic BP than thiazide, it can induce regression of LV hypertrophy similar in magnitude to thiazide. Unlike hydrochlorothiazide, exercise training can improve insulin resistance and aerobic capacity in older hypertensive people.
机译：为了比较运动训练和氢氯噻嗪对老年高血压成年人左心室（LV）几何形状和质量，血压（BP）和高胰岛素血症的影响，我们研究了28例随机分为两组的患者（66.4 +/- 1.3岁; n = 16）参加运动或一组接受氢氯噻嗪6 mo的人群（年龄65.3 +/- 1.2岁; n = 12）。耐力运动训练可将峰值有氧能力提高15％。噻嗪类药物的收缩压降低比运动量大两倍（26.6 +/- 12.2 vs. 11.5 +/- 10.9 mmHg）。运动和噻嗪可降低LV壁厚，LV质量指数（每组14％）和LV壁厚半径比（h / r）（锻炼：0.48 +/- 0.2之前，0.42 +/-之后） 0.01;噻嗪：0.47 +/- 0.04之前，0.40 +/- 0.04之后; P = 0.017）。在运动组中收缩压和h / r的降低是相关的（r = 0.70，P = 0.005），而在噻嗪类中则没有。运动训练减少了葡萄糖刺激的高胰岛素血症（之前：13.65 +/- 2.6对9.84 +/- 1.5 mU.ml（-1）.min; P 0.04）和胰岛素抵抗。噻嗪类不影响血浆胰岛素水平。结果表明，尽管运动对降低收缩压的作用不如噻嗪类，但它可以诱发LV肥大的退化，其程度与噻嗪类相似。与氢氯噻嗪不同，运动训练可以改善老年人高血压患者的胰岛素抵抗和有氧运动能力。

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