• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Physiology >Role of natriuretic peptides in regulation of conduit artery distensibility.
【24h】

Role of natriuretic peptides in regulation of conduit artery distensibility.

机译：利钠肽在调节导管动脉可扩张性中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Arterial distensibility, assessed by the pulse-wave velocity (PWV), is an independent predictor of cardiovascular risk. We investigated whether natriuretic peptides, acting locally, modify conduit artery distensibility in vivo. All studies were conducted in anesthetized sheep (n = 18) by using a validated ovine hindlimb model. In brief, the PWV was calculated, with the use of the foot-to-foot methodology, from two pressure waveforms recorded simultaneously with a high-fidelity dual pressure-sensing catheter placed in the common iliac artery. Drugs were infused either proximally, via the catheter to perfuse the segment of artery under study, or distally, via the sheath to control for any reflex changes in flow or sympathetic activation. First, the effects of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and c-type natriuretic peptide (CNP) were studied. Second, the role of endogenous ANP was investigated by infusing the natriuretic peptide receptor type A (NPRA)-selective receptor antagonist A71915. Third, A71915 was coinfused with ANP. Fourth, the NPRC-selective agonist cANF was infused. Infusion of CNP or des-[Gln18Ser19Gly20Leu21Gly22]-ANF-(4-23)-NH2 (cANF) had no effect on iliac PWV. However, infusion of ANP, and to a lesser degree BNP, resulted in a reduction in PWV (-9%; P < 0.01 and -6%; P < 0.05, respectively). A71915 increased iliac PWV from 2.97 +/- 0.13 to 3.06 +/- 0.13 m/s; P < 0.01. Coinfusion of A71915 with ANP completely abolished the effects of ANP (P < 0.01). Importantly, ANP-BNP infusion via the sheath did not alter PWV. In conclusion, ANP, and to a lesser extent BNP, modify large artery distensibility via the NPRA receptor. Neither CNP nor cANF altered PWV, suggesting that the NPRB and NPRC receptors do not acutely influence distensibility in vivo.
机译：通过脉搏波速度（PWV）评估的动脉扩张性是心血管风险的独立预测因子。我们调查了钠利尿肽是否局部起作用，在体内改变导管动脉的扩张性。所有研究均使用经过验证的绵羊后肢模型在麻醉的绵羊（n = 18）中进行。简而言之，PWV是通过使用脚对脚方法，从同时记录在two总动脉中的高保真双压力传感导管记录的两个压力波形中计算出来的。通过导管向近端灌注药物以灌注研究中的动脉段，或者通过鞘管向远端灌注药物以控制血流或交感神经激活的任何反射变化。首先，研究了心钠素（ANP），脑钠素（BNP）和c型利钠肽（CNP）的作用。其次，通过注入A型利钠肽受体（NPRA）选择性受体拮抗剂A71915，研究了内源性ANP的作用。第三，A71915与ANP融合在一起。第四，注入NPRC选择性激动剂cANF。输注CNP或des-[[Gln18Ser19Gly20Leu21Gly22] -ANF-（4-23）-NH2（cANF）对on体PWV无影响。但是，输注ANP和少量BNP导致PWV降低（分别为-9％; P <0.01和-6％; P <0.05）。 A71915将动脉PWV从2.97 +/- 0.13 m / s增加到3.06 +/- 0.13 m / s; P ＜0.01。 A71915与ANP的共输注完全废除了ANP的作用（P <0.01）。重要的是，通过鞘管输注ANP-BNP不会改变PWV。总之，ANP和较小程度的BNP通过NPRA受体改变大动脉的扩张性。 CNP和cANF均未改变PWV，这表明NPRB和NPRC受体不会严重影响体内的可扩张性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号