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首页> 外文期刊>American Journal of Physiology >Body temperature, behavior, and plasma cortisol changes induced by chronic infusion of Staphylococcus aureus in goats.
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Body temperature, behavior, and plasma cortisol changes induced by chronic infusion of Staphylococcus aureus in goats.

机译：山羊长期输注金黄色葡萄球菌引起的体温，行为和血浆皮质醇变化。

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Most experimentally induced fevers are acute, usually lasting approximately 6-12 h, and thus do not mimic chronic natural fevers, which can extend over several days or more. To produce a model of chronic natural fever, we infused eight goats (Capra hircus) intravenously with 2 ml of 2 x 10(11) cell walls of Staphylococcus aureus (S. aureus) for 6 days using osmotic infusion pumps (10 microl/h) while measuring changes in body temperature, behavior, and plasma cortisol concentration. Seven control animals were infused with sterile saline. Abdominal temperature-sensitive data loggers and osmotic infusion pumps were implanted under halothane anesthesia. To compare our new model with existing models of experimental fever, we also administered 2-ml bolus intravenous injections of 2 x 10(11) S. aureus cell walls, 0.1 microg/kg lipopolysaccharide (Escherichia coli, serotype 0111:B4), and sterile saline in random order to six other goats. Bolus injection of lipopolysaccharide and S. aureus induced typical acutephase responses, characterized by fevers lasting approximately 6 h, sickness behavior, and increased plasma cortisol concentration. Infusion of S. aureus evoked prolonged fevers, which lasted for approximately 3 days, starting on day 4 of infusion (ANOVA, P < 0.05), and did not disrupt the normal circadian rhythm of body temperature. However, pyrogen infusion did not cause plasma cortisol concentration to rise (ANOVA, P > 0.05) or the expression of sickness behavior. In conclusion, infusion of S. aureus produced a fever response resembling that of sustained natural fevers but did not elicit the cortisol and behavioral responses that often are described clinically and during short-term experimental fevers.
机译：大多数实验诱发的发烧都是急性的，通常持续约6-12小时，因此不能模仿可能持续数天或更长时间的慢性自然发烧。为了产生慢性自然发烧的模型，我们使用渗透输液泵（10 microl / h）向2只金黄色葡萄球菌（S. aureus）的2 x 10（11）细胞壁2 ml静脉内注入八只山羊（Capra hircus） ），同时测量体温，行为和血浆皮质醇浓度的变化。七只对照动物被注入无菌盐水。在氟烷麻醉下植入腹部对温度敏感的数据记录仪和渗透输液泵。为了将我们的新模型与现有的实验发烧模型进行比较，我们还进行了2 ml大剂量静脉注射2 x 10（11）金黄色葡萄球菌细胞壁，0.1 microg / kg脂多糖（大肠杆菌，血清型0111：B4）和随机给其他六只山羊提供无菌生理盐水。小球注射脂多糖和金黄色葡萄球菌引起典型的急性期反应，其特征是持续约6小时的发烧，疾病行为和血浆皮质醇浓度增加。从输注的第4天开始，输注金黄色葡萄球菌会引起持续的发烧，持续约3天（ANOVA，P <0.05），并且不会破坏正常的体温昼夜节律。然而，输注热原并未引起血浆皮质醇浓度升高（ANOVA，P> 0.05）或疾病行为的表达。总之，输注金黄色葡萄球菌会产生类似于持续自然发烧的发烧反应，但并未引起通常在临床和短期实验性发烧中描述的皮质醇和行为反应。

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