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首页> 外文期刊>American Journal of Physiology >Relationship between arterial diameter and perfused tissue volume in myocardial microcirculation: a micro-CT-based analysis.
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Relationship between arterial diameter and perfused tissue volume in myocardial microcirculation: a micro-CT-based analysis.

机译：心肌微循环中动脉直径与灌注组织体积之间的关系：基于微CT的分析。

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The volume of myocardial tissue that is perfused by an epicardial coronary artery has been shown to be predictably related to the diameter of the epicardial arterial lumen. However, to what extent the intramyocardial microvasculature follows the epicardial rules remains unclear. To explore the relationship between the diameter of coronary arterioles and their subsequent perfused myocardial volumes, we quantified the volume of nonperfused myocardium resulting from an embolized arteriole of a certain diameter. We injected a single dose of microspheres selected from one of nine possible microsphere combinations (10, 30, and 100 microm diameter, each at three possible doses) into the left anterior descending coronary and/or left circumflex arteries of seven anesthetized pigs. At postmortem, the coronary arteries were infused with a radiopaque silicon polymer. Embolized myocardium (1 cm(3)) was scanned with a microcomputerized tomography scanner and resulted in three-dimensional images that consisted of 20 microm/side cubic voxels and a subvolume of the specimen with 4 microm/side cubic voxels. Image analysis provided the number and volumes of myocardial perfusion defects for each size and dose of microspheres. The smallest individual myocardial perfusion defects, which correspond to the volume of myocardium perfused by a single embolized arteriole, were found to be 0.0004 +/- 0.0002, 0.02 +/- 0.004, and 0.62 +/- 0.099 mm(3) for the 10-, 30-, and 100-microm microspheres, respectively. The number of myocardial perfusion defects in the embolized myocardium was inversely related to the dose of the injected microspheres. This reflects a clustering behavior that is consistent with a random distribution process of the individual embolized perfusion defects.
机译：已经显示出由心外膜冠状动脉灌注的心肌组织的体积与心外膜动脉腔的直径可预测地相关。但是，尚不清楚心肌内微血管遵循心外膜规则的程度。为了探究冠状小动脉的直径与其随后的灌注心肌体积之间的关系，我们量化了由一定直径的栓塞小动脉产生的非灌注心肌的体积。我们将七种猪的左前降支和/或左旋支动脉中的9种可能的微球组合之一（直径分别为10、30和100微米，分别以3种可能的剂量）中的一种注射到微球中。死后，将不透射线的硅聚合物注入冠状动脉。用微型计算机断层扫描仪扫描栓塞的心肌（1 cm（3）），并产生三维图像，该三维图像包含20微米/侧立方体素和一个小体积的标本，其中包含4微米/侧立方体素。图像分析提供了每种大小和剂量的微球的心肌灌注缺陷的数量和体积。发现10个最小的单个心肌灌注缺陷对应于单个栓塞小动脉灌注的心肌体积，分别为0.0004 +/- 0.0002、0.02 +/- 0.004和0.62 +/- 0.099 mm（3） -，30和100微米微球。栓塞心肌中心肌灌注缺陷的数量与注射微球的剂量成反比。这反映出与单个栓塞灌注缺陷的随机分布过程一致的聚集行为。

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