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首页> 外文期刊>American Journal of Physiology >Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enhanced after exercise training in lung transplant skeletal muscle.
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Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enhanced after exercise training in lung transplant skeletal muscle.

机译：在肺移植骨骼肌中进行运动训练后，腺嘌呤核苷酸转位酶和线粒体肌酸激酶的功能偶联增强。

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摘要

Mechanisms responsible for limitation of exercise capacity in lung transplant recipients (LR) and benefits gained by exercise training were studied. Mitochondrial respiration parameters, energy transfer, and cell structure were assessed in vastus lateralis biopsies using the permeabilized fiber technique with histochemical and morphometric measurements. Twelve male controls (C) and 12 LR performed exercise training over 12 wk. Before exercise training, there were strong correlations between exercise capacity (maximal O(2) consumption and endurance time at 70% maximal power output) and cellular events, as assessed by percentage of type I fibers and apparent K(m) for exogenous ADP. Anticalcineurins were not involved in LR exercise limitation, since there were no differences in maximal mitochondrial rate of respiration before exercise training and no abnormalities in respiratory chain complexes compared with C. Training resulted in a significant increase in physiological parameters both at the cellular (apparent K(m) for exogenous ADP and stimulating effect of creatine) and integrated (maximal O(2) consumption, power output at ventilatory threshold, maximal power output, and endurance time at 70% maximal power output) levels in LR and C. After the training period, improvements in maximal O(2) consumption and in maximal mitochondrial rate of respiration were noted, as well as changes in endurance time and percentage of type I fibers. Because there were no changes in diameters and fiber types, baseline alteration of apparent K(m) for exogenous ADP and its improvement after training might be related to changes within the intracellular energetic units. After the training period, intracellular energetic units exhibited a higher control of mitochondrial respiration by creatine linked to a more efficient functional coupling adenine nucleotide translocase-mitochondrial creatine kinase, resulting in better exercise performances in C and LR.
机译：研究了造成肺移植受者（LR）运动能力受限的机制以及通过运动训练获得的益处。使用透化纤维技术结合组织化学和形态学测量，在股外侧肌活检中评估线粒体呼吸参数，能量转移和细胞结构。 12名男性对照（C）和12名LR进行了超过12周的运动训练。在运动训练之前，运动能力（最大O（2）消耗量和最大功率输出的70％的耐力时间）与细胞事件之间具有很强的相关性，如通过I型纤维的百分比和表观K（m）评估外源性ADP。与C相比，抗钙调神经磷酸酶不参与LR运动限制，因为在运动训练之前最大线粒体呼吸速率没有差异，并且呼吸链复合物也没有异常。训练导致细胞（表观K）的生理参数显着增加（m）用于外源ADP和肌酸的刺激作用）和LR和C的综合水平（最大O（2）消耗量，通气阈值下的功率输出，最大功率输出和最大功率输出70％的续航时间）。训练期间，注意到最大O（2）消耗量和最大线粒体呼吸速率的改善，以及耐力时间和I型纤维百分比的变化。由于直径和纤维类型没有变化，外源ADP的表观K（m）的基线变化及其在训练后的改善可能与细胞内高能单位内的变化有关。在训练期之后，细胞内高能单位通过与更有效的功能性腺嘌呤核苷酸转位酶-线粒体肌酸激酶功能连接的肌酸表现出更高的线粒体呼吸控制，从而在C和LR中表现出更好的运动表现。

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