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首页> 外文期刊>American Journal of Physiology >Dynamic and static baroreflex control of muscle sympathetic nerve activity (SNA) parallels that of renal and cardiac SNA during physiological change in pressure.
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Dynamic and static baroreflex control of muscle sympathetic nerve activity (SNA) parallels that of renal and cardiac SNA during physiological change in pressure.

机译：动态和静态压力反射控制肌肉交感神经活动（SNA）与生理压力变化时肾脏和心脏SNA平行。

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摘要

Despite accumulated knowledge on human baroreflex control of muscle sympathetic nerve activity (SNA), whether baroreflex control of muscle SNA parallels that of other SNAs, in particular renal and cardiac SNAs, remains unclear. Using urethane and alpha-chloralose-anesthetized, vagotomized and aortic-denervated rabbits (n = 10), we recorded muscle SNA from tibial nerve by microneurography, simultaneously with renal and cardiac SNAs by wire electrode. To produce a baroreflex open-loop condition, we isolated the carotid sinuses from systemic circulation and altered the intracarotid sinus pressure (CSP) according to a binary white noise sequence of operating pressure +/- 20 mmHg (for investigating dynamic characteristics of baroreflex) or in stepwise 20-mmHg increments from 40 to 160 mmHg (for investigating static characteristics of baroreflex). Dynamic high-pass characteristics of baroreflex control of muscle SNA, assessed by the increasing slope of transfer gain, showed that more rapid change of arterialpressure resulted in greater response of muscle SNA to pressure change and that these characteristics were similar to cardiac SNA but greater than renal SNA. However, numerical simulation based on the transfer function shows that the differences in dynamic baroreflex control at various organs result in detectable differences among SNAs only when CSP changes at unphysiologically high rates (i.e., 5 mmHg/s). On the other hand, static reverse-sigmoid characteristics of baroreflex control of muscle SNA agreed well with those of renal or cardiac SNAs. In conclusion, dynamic-linear and static-nonlinear baroreflex control of muscle SNA is similar to that of renal and cardiac SNAs under physiological pressure change.
机译：尽管人们对肌肉交感神经活动（SNA）的压力反射控制有积累的知识，但对肌肉SNA的压力反射控制是否与其他SNA，尤其是肾脏和心脏SNA的压力反射控制相似尚不清楚。使用氨基甲酸乙酯和α-氯草胺麻醉的，迷走神经切断的和主动脉去神经的兔子（n = 10），我们通过微神经造影术记录了胫神经的肌肉SNA，同时通过线电极记录了肾脏和心脏SNA。为了产生压力感受器开环状态，我们根据系统压力+/- 20 mmHg的二值白噪声序列（用于研究压力感受器的动态特性）从系统循环中分离出颈动脉窦并改变颈动脉窦压力（CSP）或以20毫米汞柱的增量从40毫米汞柱逐步增加到160毫米汞柱（用于研究压力反射的静态特性）。通过转移增益斜率的增加来评估肌肉SNA的压力反射控制的动态高通特性，结果表明，动脉压变化越快，肌肉SNA对压力变化的反应越大，这些特性与心脏SNA类似，但大于肾脏SNA。但是，基于传递函数的数值模拟表明，只有当CSP以非生理性高速率（即5 mmHg / s）变化时，各个器官的动态压力反射控制的差异才会导致SNA之间可检测到的差异。另一方面，肌肉SNA的压力反射控制的静态反S形特征与肾脏或心脏SNA的特征非常吻合。总之，在生理压力变化下，肌肉SNA的动态-线性和静态-非线性压力反射控制类似于肾脏和心脏SNA的控制。

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