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首页> 外文期刊>American Journal of Physiology >Comparative effects of single- and linear triple-site rapid bipolar pacing on atrial activation in canine models.
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Comparative effects of single- and linear triple-site rapid bipolar pacing on atrial activation in canine models.

机译：单点和线性三点快速双极起搏对犬模型心房激活的比较作用。

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摘要

Nonuniform conduction may cause block and/or delay, thereby providing a substrate for the onset and maintenance of reentrant atrial arrhythmias. We tested the hypothesis that linear triple-site, bipolar, rapid pacing (LTSBRP) of the right atrium generates more uniform wave-front propagation compared with single-site, bipolar, rapid pacing (SSBRP), thereby reducing and/or eliminating conduction block and delay that is otherwise present. Five dogs with pericarditis and three normal dogs were studied. Three plunge-wire electrode pairs were placed 5-7 mm apart in both perpendicular and parallel configurations at the superior aspect of the crista terminalis and were used to pace at 200- and 300-ms cycle lengths for < or 6 s. During pacing, 380 electrograms were recorded simultaneously from electrode arrays placed epicardially on the atria, which produced activation sequence maps for each pacing episode. Local conduction-velocity vectors were computed for each site during each episode. Histograms of absolutevelocity vector angles from the x-axis (of the crista terminalis) were plotted to assess uniformity of wave-front propagation, and the magnitude of each vector was computed to assess the local speed. LTSBRP showed 1) more uniform linear activation wave fronts compared with SSBRP, 2) velocity vectors with a more uniform magnitude and direction compared with SSBRP, 3) a predominant absolute velocity vector angle vs. a scattered angle distribution with SSBRP, and 4) shorter right atrial activation time and faster mean epicardial speed than SSBRP for each pacing cycle length. LTSBRP created a more uniform wave-front propagation with less or no conduction block and/or delay compared with SSBRP.
机译：不均匀的传导可能导致阻塞和/或延迟，从而为折返性房性心律失常的发作和维持提供基础。我们测试了以下假设：与单部位，双极，快速起搏（SSBRP）相比，右心房的线性三部位，双极，快速起搏（LTSBRP）产生更均匀的波前传播，从而减少和/或消除了传导阻滞和延迟，否则会出现。研究了五只患有心包炎的狗和三只正常的狗。将三对插线式电极对以垂直和平行配置分别在the终端的上侧以5-7 mm的间隔放置，并用于以200毫秒和300毫秒的周期长度进行<或6 s的步伐。在起搏过程中，同时从心外膜放置在心房上的电极阵列中记录了380个电描记图，这产生了每个起搏事件的激活序列图。在每个发作期间针对每个部位计算局部传导速度向量。绘制了从x轴（crista末端的）绝对速度矢量角度的直方图，以评估波前传播的均匀性，并计算每个矢量的大小以评估局部速度。 LTSBRP显示1）与SSBRP相比更均匀的线性激活波前，2）与SSBRP相比速度和方向更均匀的速度矢量，3）在SSBRP时主要的绝对速度矢量角与散射角分布有关，以及4）较短对于每个起搏周期长度，右心房激活时间和平均心外膜速度均比SSBRP快。与SSBRP相比，LTSBRP产生了更均匀的波前传播，具有更少或没有传导阻滞和/或延迟。

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