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首页> 外文期刊>American Journal of Physiology >Demonstration of functional role of TECK/CCL25 in T lymphocyte-endothelium interaction in inflamed and uninflamed intestinal mucosa
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Demonstration of functional role of TECK/CCL25 in T lymphocyte-endothelium interaction in inflamed and uninflamed intestinal mucosa

机译：证明TECK / CCL25在发炎和未发炎肠粘膜中T淋巴细胞-内皮相互作用中的功能作用

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摘要

It has recently been suggested that C-C chemokines may play a role in the organ-specific homing of lymphocytes, but there is not enough in vivo evidence in intestinal mucosa. The aim of this study was to examine whether thymus-expressed chemokine (TECK)/CCL25 and its ligand CCR9 are involved in T-lymphocyte interaction with microvessels of murine intestinal mucosa. T lymphocytes from the small intestine were fluorescence labeled, and their adhesion to mucosal microvessels was observed by intravital microscopy. Lamina proprial lymphocytes (LPL) and intraepithelial lymphocytes (IEL) adhered to both the small intestine and colon, and desensitization of CCR9 with TECK/CCL25 or anti-TECK/CCL25 antibody significantly inhibited these adhesions only in small intestine.
机译：最近已经提出C-C趋化因子可能在淋巴细胞的器官特异性归巢中起作用，但是在肠粘膜中没有足够的体内证据。这项研究的目的是检查胸腺表达的趋化因子（TECK）/ CCL25及其配体CCR9是否参与T淋巴细胞与鼠肠粘膜微血管的相互作用。对来自小肠的T淋巴细胞进行荧光标记，并通过活体显微镜观察它们对粘膜微血管的粘附。薄层固有淋巴细胞（LPL）和上皮内淋巴细胞（IEL）附着在小肠和结肠，并且用TECK / CCL25或抗TECK / CCL25抗体使CCR9脱敏仅在小肠中显着抑制了这些粘附。

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